| Themes in fibrosis and gastrointestinal inflammation. | |
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MedLine Citation:
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PMID: 21415411 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Wound healing is an appropriate response to inflammation and tissue injury in the gastrointestinal tract. If wound healing responses are excessive, perpetuated, or prolonged, they lead to fibrosis, distortion of tissue architecture, and loss of function. This introductory editorial and the minireviews or reviews in this themes series highlight the diversity in severity and location of fibrosis in response to gastrointestinal inflammation. The multiplicity of cellular and molecular mediators and new players, including stem cells or extracellular matrix-producing cells derived from nonmesenchymal cell types, is reviewed. Comparisons of inflammation-induced fibrosis across organ systems and the need for integrated and systems-based molecular approaches, new imaging modalities, well-characterized animal models, cell culture models, and improved diagnostic or predictive markers are reviewed. To date, intestinal fibrosis has received much less attention than inflammation in terms of defining mechanisms and underlying causes. This themes series aims to illustrate the importance of research in this area in gastrointestinal health and disease. |
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Authors:
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Claudio Fiocchi; P Kay Lund |
Publication Detail:
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Type: Editorial; Introductory Journal Article; Research Support, N.I.H., Extramural Date: 2011-03-17 |
Journal Detail:
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Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 300 ISSN: 1522-1547 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-28 Completed Date: 2011-06-28 Revised Date: 2012-05-01 |
Medline Journal Info:
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Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: United States |
Other Details:
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Languages: eng Pagination: G677-83 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Environment Extracellular Matrix / pathology Fibrosis Gastrointestinal Diseases / pathology*, therapy Humans Inflammation / pathology* Intestines / microbiology Liver Cirrhosis / pathology*, therapy |
| Grant Support | |
ID/Acronym/Agency:
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DK047769-11/DK/NIDDK NIH HHS; DK069854-5/DK/NIDDK NIH HHS; DK50984-10/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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