Document Detail


Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology.
MedLine Citation:
PMID:  19244215     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eicosanoids have been implicated in a vast number of devastating inflammatory conditions, including arthritis, atherosclerosis, pain, and cancer. Currently, over a hundred different eicosanoids have been identified, with many having potent bioactive signaling capacity. These lipid metabolites are synthesized de novo by at least 50 unique enzymes, many of which have been cloned and characterized. Due to the extensive characterization of eicosanoid biosynthetic pathways, this field provides a unique framework for integrating genomics, proteomics, and metabolomics toward the investigation of disease pathology. To facilitate a concerted systems biology approach, this review outlines the proteins implicated in eicosanoid biosynthesis and signaling in human, mouse, and rat. Applications of the extensive genomic and lipidomic research to date illustrate the questions in eicosanoid signaling that could be uniquely addressed by a thorough analysis of the entire eicosanoid proteome.
Authors:
Matthew W Buczynski; Darren S Dumlao; Edward A Dennis
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-02-24
Journal Detail:
Title:  Journal of lipid research     Volume:  50     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-18     Completed Date:  2009-08-12     Revised Date:  2013-06-12    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1015-38     Citation Subset:  IM    
Affiliation:
Department of Chemistry and Biochemistry, Department of Pharmacology, and School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arachidonate 5-Lipoxygenase / metabolism
Cytochrome P-450 Enzyme System / metabolism
Eicosanoids / physiology*
Humans
Lipoxygenase / metabolism
Metabolomics
Models, Biological
Phospholipases A2 / metabolism
Prostaglandin-Endoperoxide Synthases / metabolism
Proteomics
Signal Transduction
Systems Biology
Grant Support
ID/Acronym/Agency:
2T32DK007202-32/DK/NIDDK NIH HHS; GM20501/GM/NIGMS NIH HHS; GM64611/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Eicosanoids; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.13.11.12/Lipoxygenase; EC 1.13.11.34/Arachidonate 5-Lipoxygenase; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases; EC 3.1.1.4/Phospholipases A2
Comments/Corrections
Erratum In:
J Lipid Res. 2009 Jul;50(7):1505

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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