Document Detail

Theanine, r-glutamylethylamide, increases neurotransmission concentrations and neurotrophin mRNA levels in the brain during lactation.
MedLine Citation:
PMID:  17904164     Owner:  NLM     Status:  MEDLINE    
Theanine (r-glutamylethylamide) is one of the major amino acid components in green tea. Recent studies suggest that theanine affects neurotransmission, especially inhibitory neurotransmission. In this study, we investigated whether theanine affects brain development in infant rats, because inhibitory neurotransmission is required for mature brain function. Mother rats were fed theanine ad libitum after confinement. The body weight gain rate of infants was not different from control infants. We detected theanine in the infant serum and measured neurotransmitter concentration and nerve growth factor (NGF) mRNA level in the infant rat brain. Some neurotransmitters, including dopamine, serotonin, glycine and GABA concentration, increased in the infant brain and NGF mRNA level increased in the cerebral cortex and hippocampus. However, these differences were lost by the end of nerve maturity. These results suggest that theanine enhanced synthesis of nerve growth factor and neurotransmitters during a nerve maturing period and promoted central nerve system maturation (CNS). Thus, theanine accelerated maturation. In conclusion, theanine may assist in healthy brain function development.
Takashi Yamada; Takehiko Terashima; Keiko Wada; Sakiko Ueda; Mitsuyo Ito; Tsutomu Okubo; Lekh Raj Juneja; Hidehiko Yokogoshi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-31
Journal Detail:
Title:  Life sciences     Volume:  81     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-10-15     Completed Date:  2007-11-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1247-55     Citation Subset:  IM    
Laboratory of Nutritional Biochemistry, COE Program in the 21st Century and CITY AREA, Ministry of Education, Culture, Sports, Science and Technology of Japan, University of Shizuoka, 52-1 Yada, Shizuoka, Japan.
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MeSH Terms
Amino Acids / blood,  metabolism
Animals, Newborn
Body Weight / drug effects
Brain* / drug effects,  growth & development,  metabolism
Glutamates / isolation & purification,  pharmacokinetics,  pharmacology*
Lactation / metabolism*
Milk / metabolism
Nerve Growth Factors / biosynthesis*
Neurotransmitter Agents / biosynthesis*
RNA, Messenger / biosynthesis*
Rats, Wistar
Tea / chemistry
Reg. No./Substance:
0/Amino Acids; 0/Glutamates; 0/Nerve Growth Factors; 0/Neurotransmitter Agents; 0/RNA, Messenger; 0/Tea; 3081-61-6/theanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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