Document Detail

Thallium-201 scintigraphy after intravenous infusion of adenosine compared with exercise thallium testing in the diagnosis of coronary artery disease.
MedLine Citation:
PMID:  2016445     Owner:  NLM     Status:  MEDLINE    
Adenosine is an endogenously produced compound that has significant effects as a coronary and systemic vasodilator. Previous studies suggest that intravenous infusion of adenosine, coupled with thallium-201 scintigraphy, may have specific value as a noninvasive means of evaluating coronary artery disease. The purpose of this study was to compare the diagnostic value of adenosine thallium testing with that of standard exercise thallium testing. One hundred subjects were studied with exercise thallium imaging and thallium imaging after adenosine infusion, including 47 with angiographically proved coronary artery disease and 53 control subjects. The overall sensitivity of the thallium procedures was 81% for the exercise study and 83% for the adenosine study (p = NS); the specificity was 74% for the exercise study and 75% for the adenosine study (p = NS). The diagnostic accuracy of the exercise study was 77% and that of the adenosine study was 79%. Ninety-four percent of subjects had an adverse effect due to the adenosine infusion; however, most of these effects were mild and well tolerated. All adverse effects abated within 30 to 45 s of the termination of the study, consistent with the very brief half-life of the agent. Thus, thallium-201 scintigraphy after intravenous infusion of adenosine has a diagnostic value similar to that of exercise thallium testing for evaluation of coronary artery disease. Adenosine thallium testing may be particularly useful in evaluating patients unable to perform treadmill exercise testing.
E P Coyne; D A Belvedere; P R Vande Streek; F L Weiland; R B Evans; L J Spaccavento
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  17     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-05-23     Completed Date:  1991-05-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1289-94     Citation Subset:  AIM; IM    
Department of Medicine, Wilford Hall United States Air Force Medical Center, Lackland Air Force Base, Texas.
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MeSH Terms
Adenosine / adverse effects,  diagnostic use*
Coronary Disease / diagnosis*,  physiopathology,  radionuclide imaging
Exercise Test*
Heart Conduction System / drug effects
Hemodynamics / drug effects
Infusions, Intravenous
Middle Aged
Thallium Radioisotopes / adverse effects,  diagnostic use*
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Thallium Radioisotopes; 58-61-7/Adenosine
Comment In:
J Am Coll Cardiol. 1991 May;17(6):1295-6   [PMID:  2016446 ]

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