| Thallium-201 myocardial SPECT in left bundle branch block: diagnosis of myocardial ischemia with a disease-specific reference database. | |
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MedLine Citation:
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PMID: 16919576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to assess the value of a myocardial perfusion single photon emission computed tomography (SPECT) reference file for patients with left bundle branch block (LBBB). METHODS AND RESULTS: Tl-201 stress-redistribution myocardial perfusion SPECT studies of patients with complete, permanent LBBB were reviewed retrospectively. To develop a reference database, 18 patients with a low likelihood of coronary artery disease (CAD) were selected. Left ventricular regional average and standard deviation (SD) values of the reference file images were calculated. The diagnostic performance was tested on perfusion images of 49 patients with LBBB, undergoing both scintigraphic and coronary angiographic evaluation, and was compared with a commercial quantitative analysis system using a general reference database. The LBBB reference file performed significantly better in detecting epicardial CAD than did the general reference database (receiver operating characteristic area under the curve 0.835 +/- 0.06 vs 0.580 +/- 0.08, p < .01). Disease localization also was improved significantly in the territory of the left anterior descending and of the right coronary arteries. CONCLUSIONS: The use of a reference file of patients with LBBB and a low likelihood of CAD aids the detection and the localization of myocardial ischemia on Tl-201 myocardial SPECT images of this patient group. |
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Authors:
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Kristóf Zupán; Béla Kári; Géza Fontos; Péter Dékány; Oszkár Pártos |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology Volume: 13 ISSN: 1532-6551 ISO Abbreviation: J Nucl Cardiol Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-08-21 Completed Date: 2006-09-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9423534 Medline TA: J Nucl Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 521-30 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Semmelweis University, Budapest, Hungary. zkristof@freemail.hu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bundle-Branch Block
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complications,
radionuclide imaging* Coronary Artery Disease / complications, radionuclide imaging* Databases, Factual* Female Humans Image Interpretation, Computer-Assisted / methods* Male Middle Aged Myocardial Ischemia / etiology, radionuclide imaging* Radiopharmaceuticals / diagnostic use Reference Values Reproducibility of Results Sensitivity and Specificity Subtraction Technique* Thallium / diagnostic use* Tomography, Emission-Computed, Single-Photon / methods* Ventricular Dysfunction, Left / etiology, radionuclide imaging* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 7440-28-0/Thallium; 7791-12-0/thallium chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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