Document Detail

Thallium-201 myocardial SPECT in left bundle branch block: diagnosis of myocardial ischemia with a disease-specific reference database.
MedLine Citation:
PMID:  16919576     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to assess the value of a myocardial perfusion single photon emission computed tomography (SPECT) reference file for patients with left bundle branch block (LBBB). METHODS AND RESULTS: Tl-201 stress-redistribution myocardial perfusion SPECT studies of patients with complete, permanent LBBB were reviewed retrospectively. To develop a reference database, 18 patients with a low likelihood of coronary artery disease (CAD) were selected. Left ventricular regional average and standard deviation (SD) values of the reference file images were calculated. The diagnostic performance was tested on perfusion images of 49 patients with LBBB, undergoing both scintigraphic and coronary angiographic evaluation, and was compared with a commercial quantitative analysis system using a general reference database. The LBBB reference file performed significantly better in detecting epicardial CAD than did the general reference database (receiver operating characteristic area under the curve 0.835 +/- 0.06 vs 0.580 +/- 0.08, p < .01). Disease localization also was improved significantly in the territory of the left anterior descending and of the right coronary arteries. CONCLUSIONS: The use of a reference file of patients with LBBB and a low likelihood of CAD aids the detection and the localization of myocardial ischemia on Tl-201 myocardial SPECT images of this patient group.
Kristóf Zupán; Béla Kári; Géza Fontos; Péter Dékány; Oszkár Pártos
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  13     ISSN:  1532-6551     ISO Abbreviation:  J Nucl Cardiol     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-08-21     Completed Date:  2006-09-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  521-30     Citation Subset:  IM    
Department of Cardiology, Semmelweis University, Budapest, Hungary.
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MeSH Terms
Bundle-Branch Block / complications,  radionuclide imaging*
Coronary Artery Disease / complications,  radionuclide imaging*
Databases, Factual*
Image Interpretation, Computer-Assisted / methods*
Middle Aged
Myocardial Ischemia / etiology,  radionuclide imaging*
Radiopharmaceuticals / diagnostic use
Reference Values
Reproducibility of Results
Sensitivity and Specificity
Subtraction Technique*
Thallium / diagnostic use*
Tomography, Emission-Computed, Single-Photon / methods*
Ventricular Dysfunction, Left / etiology,  radionuclide imaging*
Reg. No./Substance:
0/Radiopharmaceuticals; 7440-28-0/Thallium; 7791-12-0/thallium chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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