| Thalidomide for the Treatment of Myelodysplastic Syndrome in Taiwan: Results of a Phase II Trial. | |
| | |
MedLine Citation:
|
PMID: 22843924 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: Thalidomide inhibits angiogenesis and exerts complex immunomodulatory activities. This phase II study aimed to examine the efficacy of thalidomide in Taiwanese patients with myelodysplastic syndrome (MDS). PATIENTS AND METHODS: Sixty patients [intention to treat group (ITT)] with MDS were treated with thalidomide (100 mg/day, increased by 100 mg/day weekly to a maximum of 400 mg/day) for 12 weeks. Forty-two patients of the ITT group were considered as comprising the evaluable population (EP). RESULTS: Thalidomide resulted in hematological improvement (HI) in 28% of ITT analysis and in HI in 40% of the EP. Thalidomide was more effective for MDS patients with low to intermediate-1 International Prognostic Score System scores. The response rates were 7% for ITT and 10% for EP patients. Only two patients exhibited a cytogenetic response. Net reduced levels of vascular endothelial growth factor and basic fibroblast growth factor cytokines were observed in the peripheral blood and the bone marrow of thalidomide-treated patients. CONCLUSION: Low-dose thalidomide is an effective and safe treatment for patients with low-risk MDS. |
| | |
Authors:
|
Chih-Yuan Chung; Sheng-Fung Lin; Po-Min Chen; Ming-Chih Chang; Woei-You Kao; Tsu-Yi Chao; Liang-Tsai Hsiao; Chuen-Chuan Yen; Muh-Hwa Yang; Wei-Shou Hwang; Tung-Liang Lin; Tzeon-Jye Chiou; Cheng-Shyong Chang |
Related Documents
:
|
9873174 - Psychosocial stress of patients with port wine stains and expectations of dye laser tre... 20626774 - Functioning of patients with multifocal motor neuropathy. 17540754 - Construct validity of the enneking score for measuring function in patients with malign... 21047464 - Patients' perception of pain during ultrasonic debridement: a comparison between piezoe... 17558864 - Clinical utility of serum soluble transferrin receptor levels and comparison with bone ... 20599474 - Cerebrospinal fluid profile of amyloid β42 (aβ42), htau and ubiquitin in north indian... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Anticancer research Volume: 32 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-07-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
|
Languages: eng Pagination: 3415-9 Citation Subset: IM |
Affiliation:
|
Division of Hematology and Oncology, Department of Internal Medicine, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua County 500, Taiwan, R.O.C. 15120@cch.org.tw or Tzeon-Jye Chiou, MD, Division of Transfusion Medicine, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Taipei 11217, Taiwan, R.O.C. e-mail: tjchiou@vghtpe.gov.tw. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chaperon normal goblet cells intercalated with dysplastic cells in duodenal adenomas express synapto...
Next Document: Association of location of lymph node metastases with postoperative recurrence of esophageal squamou...