Document Detail


Thalassemia trait in outpatient clinics of Sana'a City, Yemen.
MedLine Citation:
PMID:  19657839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Blood samples were collected from 699 patients attending out patient clinics in Sana'a City, Yemen, to obtain some idea of the prevalence of the thalassemias in our country. Complete blood count, hemoglobin (Hb) electrophoresis, quantitation of Hb A(2) and Hb F, and serum ferritin were determined. Microcytic, hypochromic red cells were found in 103 subjects (14.7%). Iron deficiency alone accounted for only a small proportion of these (n = 12), whereas features suggestive of beta-thalassemia (beta-thal) were present in 31 patients (4.43%) and features suggestive of alpha-thal trait were found in 60 patients (8.6%). The study showed that thalassemia probably accounts for most red cell microcytosis in these out patient clinics, and could represent a significant health problem through births of homozygotes and compound heterozygotes with severe disorders. This pilot study should be repeated with improved technology, and extended to include globin gene analysis to define the nature of the disorders that remain poorly diagnosed.
Authors:
Hafiz Al-Nood
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hemoglobin     Volume:  33     ISSN:  1532-432X     ISO Abbreviation:  Hemoglobin     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-06     Completed Date:  2010-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705865     Medline TA:  Hemoglobin     Country:  England    
Other Details:
Languages:  eng     Pagination:  242-6     Citation Subset:  IM    
Affiliation:
Department of Haematology, Sana'a University, Faculty of Medicine and Health Sciences, Sana'a, Yemen. hafizalnood@yahoo.co.uk
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Ambulatory Care Facilities / statistics & numerical data*
Child
Child, Preschool
Densitometry
Female
Ferritins / blood
Fetal Hemoglobin / analysis
Hemoglobin A2 / analysis
Humans
Infant
Male
Middle Aged
Pilot Projects
Prevalence
Yemen / epidemiology
Young Adult
alpha-Thalassemia / blood,  diagnosis*,  epidemiology
beta-Thalassemia / blood,  diagnosis*,  epidemiology
Chemical
Reg. No./Substance:
9007-73-2/Ferritins; 9034-53-1/Hemoglobin A2; 9034-63-3/Fetal Hemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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