| Thalamus and cognitive impairment in Mild Traumatic Brain Injury: A Diffusional Kurtosis Imaging Study. | |
| | |
MedLine Citation:
|
PMID: 21639753 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Conventional imaging is unable to detect damage that accounts for permanent cognitive impairment in patients with mild traumatic brain injury (MTBI). While diffusion tensor imaging (DTI) can help to detect diffuse axonal injury (DAI), it is a limited indicator of tissue complexity. It has also been suggested that the thalamus may play an important role in the development of clinical sequelae in MTBI. The purpose of this study was to determine if diffusional kurtosis imaging (DKI), a novel quantitative magnetic resonance imaging (MRI) technique, can provide early detection of damage in the thalamus and white matter (WM) of MTBI patients and if thalamic injury is associated with cognitive impairment. Twenty-two MTBI patients and 14 controls underwent MRI and neuropsychological testing. Mean kurtosis (MK), fractional anisotropy (FA), and mean diffusivity (MD) were measured in the thalamus and several WM regions classically identified with DAI. Compared to controls, patients examined within one year after injury exhibited variously altered DTI and DKI derived measures in the thalamus and the internal capsule while, in addition to these regions, patients examined more than one year after injury also showed similar differences in the splenium of the corpus callosum and the centrum semiovale. Cognitive impairment was correlated to MK in the thalamus and the internal capsule. These findings suggest that combined use of DTI and DKI provides a more sensitive tool for identifying brain injury. In addition, MK in the thalamus might be useful for early prediction of permanent brain damage and cognitive outcome. |
| | |
Authors:
|
Elan J Grossman; Yulin Ge; Jens H Jensen; James S Babb; Laura Miles; Joseph Reaume; Jonathan M Silver; Robert I Grossman; Matilde Inglese |
Related Documents
:
|
11146043 - Magnetic resonance imaging for in vivo assessment of tissue oxygen concentration. 478803 - Sequential changes in the ct numbers of the normal canine kidney following intravenous ... 22109633 - Magnetic resonance imaging of lower limb musculature in acute motor axonal neuropathy. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-3 |
Journal Detail:
|
Title: Journal of neurotrauma Volume: - ISSN: 1557-9042 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8811626 Medline TA: J Neurotrauma Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
New York University, Radiology, New York, New York, United States; elan.grossman@nyumc.org. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sowing the seeds of the autism field: leo kanner (1943).
Next Document: Medical device interoperability a standards-based testing approach.