Document Detail


Thalamic stimulation reduces essential tremor but not the delayed antagonist muscle timing.
MedLine Citation:
PMID:  11839839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Electrical stimulation of the thalamus dramatically reduces essential tremor (ET). It has been hypothesized that the cerebellum and inferior olive are involved in the generation of ET, and thalamic stimulation is presumed to dampen ET through interactions with cerebellar output to the thalamus. Evidence suggests that abnormal timing of agonist and antagonist muscle responses contribute to cerebellar tremor (CbT); however, this relationship has not been investigated for ET. The mechanisms of the tremor and improvement are unknown. OBJECTIVE: To measure the effect of ventral intermediate thalamic stimulation in controlling the ET response to sudden stretch of an agonist muscle and to determine whether, in ET, the timing relationships between the initial agonist and antagonist electromyography (EMG) responses show abnormalities similar to those seen in CbT. METHODS: The authors studied ET subjects (with implanted thalamic stimulators turned off and on) and normal controls as they responded to mechanical torque pulses given at the wrist joint. The wrist joint angle, wrist agonist, and antagonist EMG were recorded. RESULTS: Like CbT, patients with ET showed delayed onsets of antagonist EMG and excessive rebound. Thalamic stimulation reduced the tremor but did not alter the antagonist delay or the rebound. CONCLUSIONS: In ET, antagonist muscle responses to a torque pulse are similar to that in CbT. However, benefit from thalamic stimulation did not alter these EMG responses; therefore, suppression of tremor must be caused by mechanisms other than the re-establishment of normal agonist-antagonist timing.
Authors:
K M Zackowski; A J Bastian; S Hakimian; J W Mink; J S Perlmutter; W C Koller; W T Thach
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  58     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-12     Completed Date:  2002-03-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  402-10     Citation Subset:  AIM; IM    
Affiliation:
Program in Physical Therapy, Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid, St. Louis, MO 63110, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Electric Stimulation Therapy*
Electromyography
Essential Tremor / physiopathology*,  therapy*
Female
Humans
Male
Middle Aged
Muscle Contraction / physiology
Muscle, Skeletal / physiology*
Reaction Time / physiology
Ventral Thalamic Nuclei / physiology*
Grant Support
ID/Acronym/Agency:
NS 01808/NS/NINDS NIH HHS; NS 12777/NS/NINDS NIH HHS

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