| Thalamic atrophy in infants with PVL and cerebral visual impairment. | |
| | |
MedLine Citation:
|
PMID: 16500047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this retrospective study was to establish the presence and severity of cerebral visual impairment in preterm infants with PVL. We also wished to establish whether abnormalities of visual function are related to brain MRI findings and more specifically not only to the involvement of optic radiations and occipital cortex but also to changes in the thalami, that are often affected in infants with PVL. Twelve infants with cystic PVL were assessed at 1 year (+2) corrected age with a battery of tests specifically designed to assess various aspects of visual function in infancy, such as ocular movements, visual acuity, visual fields and fixation shift. All infants also had a brain MRI. Eleven of the 12 had involvement of the optic radiations: all had some abnormalities of visual function and visual impairment was more severe in infants with more extensive involvement of the optic radiations. The child with normal optic radiations had normal visual function. Six of the 12 infants also had obvious signs of atrophy of the thalami and all had severe and wide-ranging abnormalities of visual function in all testing domains. Two children had equivocal atrophy of the thalami, both had some abnormalities of visual function. Four children had normal thalami and had normal visual function or only minor abnormalities on one of the visual tests. Our results suggest that the atrophy of the thalami may play an additional role in the abnormal development of visual function in infants with PVL and abnormal optic radiations. |
| | |
Authors:
|
Daniela Ricci; Shirley Anker; Frances Cowan; Marika Pane; Francesca Gallini; Rita Luciano; Valeria Donvito; Giovanni Baranello; Laura Cesarini; Flaviana Bianco; Mary Rutherford; Costantino Romagnoli; Janette Atkinson; Oliver Braddick; Francesco Guzzetta; Eugenio Mercuri |
Related Documents
:
|
12430157 - Effect of delay interval on classical eyeblink conditioning in 5-month-old human infants. 10685987 - Correlation between visual function, neurodevelopmental outcome, and magnetic resonance... 1122417 - Stereoacuity and fusional amplitude in foveal suppression. 8865617 - Perception of auditory-visual temporal synchrony in human infants. 18720637 - Maternal mortality in bahrain 1987-2004: an audit of causes of avoidable death. 12430157 - Effect of delay interval on classical eyeblink conditioning in 5-month-old human infants. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-02-24 |
Journal Detail:
|
Title: Early human development Volume: 82 ISSN: 0378-3782 ISO Abbreviation: Early Hum. Dev. Publication Date: 2006 Sep |
Date Detail:
|
Created Date: 2006-09-04 Completed Date: 2006-10-19 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7708381 Medline TA: Early Hum Dev Country: Ireland |
Other Details:
|
Languages: eng Pagination: 591-5 Citation Subset: IM |
Affiliation:
|
Paediatric Neurology Unit, Catholic University, Rome, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Atrophy Humans Infant, Newborn Infant, Premature Leukomalacia, Periventricular / diagnosis*, pathology Magnetic Resonance Imaging Retrospective Studies Thalamus / pathology* Vision Disorders / diagnosis*, pathology Vision Tests |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Two methods for estimating age of newborns in catch-up growth studies.
Next Document: Detection of allergens adsorbed to ambient air particles collected in four European cities.