Document Detail

Thalamic activation in the kleine-levin syndrome.
MedLine Citation:
PMID:  24497666     Owner:  NLM     Status:  In-Data-Review    
STUDY OBJECTIVES: The objective of this study was to investigate if combined measures of activation in the thalamus and working memory capacity could guide the diagnosis of Kleine-Levin Syndrome (KLS). A second objective was to obtain more insight into the neurobiological causes of KLS.
DESIGN: Matched group and consecutive recruitment.
SETTING: University hospital neurology department and imaging center.
PATIENTS OR PARTICIPANTS: Eighteen patients with KLS diagnosed according to the International Classification of Sleep Disorders and 26 healthy controls were included.
MEASUREMENTS AND RESULTS: Working memory capacity was assessed by the listening span task. A version of this task (reading span) was presented to the participants during functional magnetic resonance imaging (fMRI). Activation in the thalamus was measured in a region of interest analysis. A combination of the working memory capacity and the thalamic activation measures resulted in 80% prediction accuracy, 81% sensitivity, and 78% specificity regarding the ability to separate KLS patients from healthy controls. The controls had an inverse relation between working memory capacity and thalamic activation; higher performing participants had lower thalamic activation (r = -0.41). KLS patients showed the opposite relationship; higher performing participants had a tendency to higher thalamic activation (r = -0.35).
CONCLUSIONS: This study shows that functional neuroimaging of the thalamus combined with neuropsychological assessment of working memory function provides a means to guide diagnosis of Kleine-Levin Syndrome. Results in this study also indicate that imaging of brain function and evaluation of cognitive capacity can give insights into the neurobiological mechanisms of Kleine-Levin Syndrome.
CITATION: Engström M; Karlsson T; Landtblom AM. Thalamic activation in the Kleine-Levin Syndrome. SLEEP 2014;37(2):379-386.
Maria Engström; Thomas Karlsson; Anne-Marie Landtblom
Related Documents :
15364476 - Posterior neocortical (visual cortex) lesions in the rat impair matching-to-place navig...
9517816 - Effects of hippocampal and parietal cortex lesions on the processing of multiple-object...
10495076 - The effect of excitotoxic lesions centered on the perirhinal cortex in two versions of ...
1823266 - Effects of massive telencephalic lesions on the organization of behavior in pigeons (co...
19412446 - Pharmacological manipulation of cyclic gmp levels in brain restores learning ability in...
24179776 - Electrophysiological responses to emotional prosody perception in cochlear implant users.
Publication Detail:
Type:  Journal Article     Date:  2014-02-01
Journal Detail:
Title:  Sleep     Volume:  37     ISSN:  1550-9109     ISO Abbreviation:  Sleep     Publication Date:  2014  
Date Detail:
Created Date:  2014-02-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7809084     Medline TA:  Sleep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  379-86     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Restless legs syndrome: an early clinical feature of Parkinson disease in men.
Next Document:  Decreased Connectivity between the Thalamus and the Neocortex during Human Nonrapid Eye Movement Sle...