Document Detail


Thalamic activation in the kleine-levin syndrome.
MedLine Citation:
PMID:  24497666     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
STUDY OBJECTIVES: The objective of this study was to investigate if combined measures of activation in the thalamus and working memory capacity could guide the diagnosis of Kleine-Levin Syndrome (KLS). A second objective was to obtain more insight into the neurobiological causes of KLS.
DESIGN: Matched group and consecutive recruitment.
SETTING: University hospital neurology department and imaging center.
PATIENTS OR PARTICIPANTS: Eighteen patients with KLS diagnosed according to the International Classification of Sleep Disorders and 26 healthy controls were included.
INTERVENTIONS: N/A.
MEASUREMENTS AND RESULTS: Working memory capacity was assessed by the listening span task. A version of this task (reading span) was presented to the participants during functional magnetic resonance imaging (fMRI). Activation in the thalamus was measured in a region of interest analysis. A combination of the working memory capacity and the thalamic activation measures resulted in 80% prediction accuracy, 81% sensitivity, and 78% specificity regarding the ability to separate KLS patients from healthy controls. The controls had an inverse relation between working memory capacity and thalamic activation; higher performing participants had lower thalamic activation (r = -0.41). KLS patients showed the opposite relationship; higher performing participants had a tendency to higher thalamic activation (r = -0.35).
CONCLUSIONS: This study shows that functional neuroimaging of the thalamus combined with neuropsychological assessment of working memory function provides a means to guide diagnosis of Kleine-Levin Syndrome. Results in this study also indicate that imaging of brain function and evaluation of cognitive capacity can give insights into the neurobiological mechanisms of Kleine-Levin Syndrome.
CITATION: Engström M; Karlsson T; Landtblom AM. Thalamic activation in the Kleine-Levin Syndrome. SLEEP 2014;37(2):379-386.
Authors:
Maria Engström; Thomas Karlsson; Anne-Marie Landtblom
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Publication Detail:
Type:  Journal Article     Date:  2014-02-01
Journal Detail:
Title:  Sleep     Volume:  37     ISSN:  1550-9109     ISO Abbreviation:  Sleep     Publication Date:  2014  
Date Detail:
Created Date:  2014-02-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7809084     Medline TA:  Sleep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  379-86     Citation Subset:  IM    
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