Document Detail


Th9 cells: differentiation and disease.
MedLine Citation:
PMID:  23405898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CD4(+) T-helper cells regulate immunity and inflammation through the acquisition of potential to secrete specific cytokines. The acquisition of cytokine-secreting potential, in a process termed T-helper cell differentiation, is a response to multiple environmental signals including the cytokine milieu. The most recently defined subset of T-helper cells are termed Th9 and are identified by the potent production of interleukin-9 (IL-9). Given the pleiotropic functions of IL-9, Th9 cells might be involved in pathogen immunity and immune-mediated disease. In this review, I focus on recent developments in understanding the signals that promote Th9 differentiation, the transcription factors that regulate IL-9 expression, and finally the potential roles for Th9 cells in immunity in vivo.
Authors:
Mark H Kaplan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  252     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-14     Completed Date:  2013-07-18     Revised Date:  2014-04-13    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  104-15     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Cell Communication
Cell Differentiation / immunology
Gene Expression Regulation
Genetic Pleiotropy / immunology
Humans
Immune System Diseases / immunology*,  pathology
Immunity, Innate
Interleukin-9 / genetics,  immunology*
Signal Transduction
T-Lymphocytes, Helper-Inducer / immunology*,  pathology
Transcription Factors / genetics,  immunology*
Grant Support
ID/Acronym/Agency:
AI057459/AI/NIAID NIH HHS; R01 AI057459/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Interleukin-9; 0/Transcription Factors
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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