| Th9 cells: differentiation and disease. | |
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MedLine Citation:
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PMID: 23405898 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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CD4(+) T-helper cells regulate immunity and inflammation through the acquisition of potential to secrete specific cytokines. The acquisition of cytokine-secreting potential, in a process termed T-helper cell differentiation, is a response to multiple environmental signals including the cytokine milieu. The most recently defined subset of T-helper cells are termed Th9 and are identified by the potent production of interleukin-9 (IL-9). Given the pleiotropic functions of IL-9, Th9 cells might be involved in pathogen immunity and immune-mediated disease. In this review, I focus on recent developments in understanding the signals that promote Th9 differentiation, the transcription factors that regulate IL-9 expression, and finally the potential roles for Th9 cells in immunity in vivo. |
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Authors:
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Mark H Kaplan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Immunological reviews Volume: 252 ISSN: 1600-065X ISO Abbreviation: Immunol. Rev. Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-02-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7702118 Medline TA: Immunol Rev Country: England |
Other Details:
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Languages: eng Pagination: 104-15 Citation Subset: IM |
Copyright Information:
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© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd. |
Affiliation:
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Departments of Pediatrics, and Microbiology and Immunology, Indiana University School of Medicine, HB Wells Center for Pediatric Research, Indianapolis, IN, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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