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Th2 immune skewing in pregnancy/early life, chemical exposure and the development of atopic disease and allergy.
MedLine Citation:
PMID:  25354210     Owner:  NLM     Status:  Publisher    
During the last 50 years there has been a significant increase in Western societies of atopic disease and associated allergy. The balance between functional subpopulations of Th cells determines the quality of immune response provoked by antigen. One such subpopulation - Th2 cells - is associated with the production of IgE antibody and atopic allergy, whereas, Th1 cells antagonise IgE responses and the development of allergic disease. In seeking to provide a mechanistic basis for this increased prevalence of allergic disease one proposal has been the 'hygiene hypothesis' which argues that in westernised societies reduced exposure during early childhood to pathogenic microorganisms favours the development of atopic allergy. Pregnancy is normally associated with Th2 skewing, that persists for some months in the neonate before Th1/Th2 realignment occurs. In this review we consider the immunophysiology of Th2 immune skewing during pregnancy. In particular, we explore the possibility that altered and increased patterns of exposure to certain chemicals have served to accentuate this normal Th2 skewing and therefore promote further the persistence of a Th2 bias in neonates. Furthermore we propose that the more marked Th2 skewing observed in first pregnancy may, at least in part, explain he higher prevalence of atopic disease and allergy in the first born. This article is protected by copyright. All rights reserved.
J P McFadden; J P Thyssen; D A Basketter; P Puangpet; I Kimber
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-29
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-29     Completed Date:  -     Revised Date:  2014-10-30    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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