Document Detail

Th2-dependent cytokine release in patients treated with coronary angioplasty.
MedLine Citation:
PMID:  18418228     Owner:  NLM     Status:  MEDLINE    
AIM: The aim of this study is to investigate the T helper (Th)2-dependent release of interleukin(IL)-4 and IL-13 in patients with unstable angina treated with coronary angioplasty (PCI). METHODS: This study involved 48 consecutive patients with unstable angina who underwent PCI. Blood samples were taken before and 48 h after PCI to evaluate serum IL-4 and IL-13 levels. Coronary atherosclerosis was assessed in terms of the severity of the treated lesions and the presence of multivessel disease, and compared with IL release. RESULTS: Before and after PCI, serum IL-4 levels were, respectively, 53.1+/-110.7 and 35.1+/-16.9 pg/ml (P not significant), and serum IL-13 levels 6.7+/-3.7 and 6.0+/-2.9 pg/ml (P<0.05). A correlation was present between the severity of the treated coronary lesions and serum IL-13 levels (r 0.36; P<0.05). The patients with multivessel coronary artery disease had a higher periprocedure ratio of IL-4 than those with single-vessel coronary artery disease (1.46+/-0.76 vs. 0.89+/-0.34, P<0.001). CONCLUSION: A significant decrease was observed in Th2-dependent IL concentrations after PCI; increased Th2-dependent IL levels before PCI seem to correlate with the severity of coronary atherosclerosis.
Natale Daniele Brunetti; Martino Pepe; Irene Munno; Fabio Tiecco; Donato Quagliara; Luisa De Gennaro; Antonio Gaglione; Matteo Di Biase; Stefano Favale
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Coronary artery disease     Volume:  19     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-17     Completed Date:  2008-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  133-7     Citation Subset:  IM    
Cardiology Department, University of Foggia, Italy.
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MeSH Terms
Angina, Unstable / blood*,  therapy
Angioplasty, Transluminal, Percutaneous Coronary*
Cohort Studies
Coronary Artery Disease / blood*,  pathology
Interleukin-13 / blood*
Interleukin-4 / blood*
Middle Aged
T-Lymphocytes, Helper-Inducer / metabolism*
Reg. No./Substance:
0/Interleukin-13; 207137-56-2/Interleukin-4

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