Document Detail


The Th1:th2 dichotomy of pregnancy and preterm labour.
MedLine Citation:
PMID:  22719180     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnancy is a unique immunological state in which a balance of immune tolerance and suppression is needed to protect the fetus without compromising the mother. It has long been established that a bias from the T helper 1 cytokine profile towards the T helper 2 profile contributes towards successful pregnancy maintenance. The majority of publications that report on aberrant Th1:Th2 balance focus on early pregnancy loss and preeclampsia. Over the last few decades, there has been an increased awareness of the role of infection and inflammation in preterm labour, and the search for new biomarkers to predict preterm labour continues. In this paper, we explore the evidence for an aberrant Th1:Th2 profile associated with preterm labour. We also consider the potential for its use in screening women at high risk of preterm labour and for prophylactic therapeutic measures for the prevention of preterm labour and associated neonatal adverse outcomes.
Authors:
Lynne Sykes; David A MacIntyre; Xiao J Yap; Tiong Ghee Teoh; Phillip R Bennett
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-06-07
Journal Detail:
Title:  Mediators of inflammation     Volume:  2012     ISSN:  1466-1861     ISO Abbreviation:  Mediators Inflamm.     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-21     Completed Date:  2012-09-26     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  9209001     Medline TA:  Mediators Inflamm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  967629     Citation Subset:  IM    
Affiliation:
Parturition Research Group, Department of Surgery and Cancer, Institute of Reproduction and Developmental Biology, Imperial College London, London W12 0NN, UK. l.sykes@imperial.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Obstetric Labor, Premature / immunology*
Pregnancy
Th1 Cells / immunology,  metabolism*
Th2 Cells / immunology,  metabolism*
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