| The Th17 immune response in renal inflammation. | |
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MedLine Citation:
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PMID: 20375986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The discovery of interleukin (IL)-17-producing CD4(+) T (Th17) cells as a unique T-helper cell lineage has revised our understanding of T-cell-mediated tissue injury. Recent data from studies in humans and mice indicate that autoimmune diseases such as multiple sclerosis and rheumatoid arthritis, classically believed to be Th1-mediated, are predominantly driven by a Th17 immune response. IL-17 (IL-17A), IL-17F, IL-21, IL-22, and possibly also IL-9 produced by Th17 cells promote inflammation by directly causing tissue injury and enhancing secretion of pro-inflammatory cytokines and chemokines by resident cells. This results in augmented infiltration of leukocytes, in particular neutrophils, to the affected tissue where they induce organ inflammation and injury. Recent studies have highlighted the potential importance of the Th17 immune response also in renal inflammatory disease. This includes the identification and characterization of IL-17-producing T cells in nephritic kidneys of mice and humans, as well as evidence for the contribution of IL-17 and the IL-23/Th17 axis to renal tissue injury in glomerulonephritis. In this review, we will briefly summarize general characteristics of Th17 cells and discuss in detail the potential role of the Th17 immune response in human and experimental renal inflammation with a special focus on glomerulonephritis. |
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Authors:
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Jan-Eric Turner; Hans-Joachim Paust; Oliver M Steinmetz; Ulf Panzer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-04-14 |
Journal Detail:
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Title: Kidney international Volume: 77 ISSN: 1523-1755 ISO Abbreviation: Kidney Int. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-28 Completed Date: 2010-09-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
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Languages: eng Pagination: 1070-5 Citation Subset: IM |
Affiliation:
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III Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, 20246 Hamburg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Glomerulonephritis / immunology, pathology Humans Inflammation / immunology* Interleukin-17 / immunology* Kidney / pathology* T-Lymphocytes, Helper-Inducer / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-17 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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