Document Detail

The Th17 family: flexibility follows function.
MedLine Citation:
PMID:  23405897     Owner:  NLM     Status:  MEDLINE    
Discovery of the T-helper 17 (Th17) subset heralded a major shift in T-cell biology and immune regulation. In addition to defining a new arm of the adaptive immune response, studies of the Th17 pathway have led to a greater appreciation of the developmental flexibility, or plasticity, that is a feature of T-cell developmental programs. Since the initial finding that differentiation of Th17 cells is promoted by transforming growth factor-β (TGFβ), it became clear that Th17 cell development overlapped that of induced regulatory T (iTreg) cells. Subsequent findings established that Th17 cells are also unusually flexible in their late developmental programming, demonstrating substantial overlap with conventional Th1 cells through mechanisms that are just beginning to be understood but would appear to have important implications for immunoregulation at homeostasis and in immune-mediated diseases. Herein we examine the developmental and functional features of Th17 cells in relation to iTreg cells, Th1 cells, and Th22 cells, as a basis for understanding the contributions of this pathway to host defense, immune homeostasis, and immune-mediated disease.
Rajatava Basu; Robin D Hatton; Casey T Weaver
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  252     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-14     Completed Date:  2013-07-18     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  89-103     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
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MeSH Terms
Cell Differentiation
Forkhead Transcription Factors / genetics,  immunology
Gene Expression Regulation
Homeostasis / immunology*
Interferon-gamma / genetics,  immunology
Interleukin-12 / genetics,  immunology
Interleukin-17 / genetics,  immunology
Nuclear Receptor Subfamily 1, Group F, Member 3 / genetics,  immunology
Signal Transduction
T-Lymphocytes, Regulatory / cytology,  immunology*
Th1 Cells / cytology,  immunology
Th17 Cells / cytology,  immunology*
Transforming Growth Factor beta / genetics,  immunology*
Grant Support
Reg. No./Substance:
0/FOXP3 protein, human; 0/Forkhead Transcription Factors; 0/Interleukin-17; 0/Nuclear Receptor Subfamily 1, Group F, Member 3; 0/RORC protein, human; 0/Transforming Growth Factor beta; 187348-17-0/Interleukin-12; 82115-62-6/Interferon-gamma

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