| Th17 cells: new players in asthma pathogenesis. | |
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MedLine Citation:
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PMID: 21375540 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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To cite this article: Cosmi L, Liotta F, Maggi E, Romagnani S, Annunziato F. Th17 cells: new players in asthma pathogenesis. Allergy 2011; DOI: 10.1111/j.1398-9995.2011.02576.x. ABSTRACT: CD4+ T effector lymphocytes are distinguished in different subsets on the basis of their patterns of cytokine secretion. Th1 cells, thank to IFN-γ production, are responsible for cell-mediated immunity against intracellular pathogens, Th2 cells, through the production of IL-4, provide some degree of protection against helminthes, and Th17 cells, via IL-17, promote neutrophils recruitment for the clearance of bacteria and fungi. However, beyond their protective role, these T-helper subsets can also be involved in the pathogenesis of several inflammatory diseases. Asthma is an inflammatory disease characterized by different clinical phenotypes. Allergic asthma is the result of an inflammatory process driven by allergen-specific Th2 lymphocytes, whereas Th17 cells are mainly involved in those forms of asthma, where neutrophils more than eosinophils, contribute to the inflammation. The identification in allergic asthma of Th17/Th2 cells, able to produce both IL-4 and IL-17, is in keeping with the observation that different clinical phenotypes can coexist in the same patient. In conclusion, a picture in which different T-cell subpopulations are active in different phase of bronchial asthma is emerging, and the wide spectrum of clinical phenotypes is probably the expression of different cellular characters playing a role in lung inflammation. |
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Authors:
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L Cosmi; F Liotta; E Maggi; S Romagnani; F Annunziato |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-6 |
Journal Detail:
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Title: Allergy Volume: - ISSN: 1398-9995 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804028 Medline TA: Allergy Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel therapies, University of Florence, Florence, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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