Document Detail


Th17 cells mediate clade-specific, serotype-independent mucosal immunity.
MedLine Citation:
PMID:  22195749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The interleukin-17 (IL-17) family of cytokines phylogenetically predates the evolution of T cells in jawed vertebrates, suggesting that the ontogeny of the Th17 cell lineage must have arisen to confer an evolutionary advantage to the host over innate sources of IL-17. Utilizing a model of mucosal immunization with the encapsulated bacteria Klebsiella pneumoniae, we found that B cells, which largely recognized polysaccharide capsular antigens, afforded protection to only the vaccine strain. In contrast, memory Th17 cells proliferated in response to conserved outer membrane proteins and conferred protection against several serotypes of K. pneumoniae, including the recently described multidrug resistant New Dehli metallolactamase strain. Notably, this heterologous, clade-specific protection was antibody independent, demonstrating the Th17 cell lineage confers a host advantage by providing heterologous mucosal immunity independent of serotype-specific antibody.
Authors:
Kong Chen; Jeremy P McAleer; Yuan Lin; David L Paterson; Mingquan Zheng; John F Alcorn; Casey T Weaver; Jay K Kolls
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Immunity     Volume:  35     ISSN:  1097-4180     ISO Abbreviation:  Immunity     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-26     Completed Date:  2012-02-23     Revised Date:  2014-10-28    
Medline Journal Info:
Nlm Unique ID:  9432918     Medline TA:  Immunity     Country:  United States    
Other Details:
Languages:  eng     Pagination:  997-1009     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Bacterial / immunology,  metabolism
Bacterial Outer Membrane Proteins / immunology
Cross Protection / immunology
Cytokines / immunology,  metabolism
Immunity, Mucosal / immunology*
Klebsiella Infections / immunology
Klebsiella pneumoniae / immunology*
Mice
Mice, Inbred C57BL
Mice, Knockout
Mucous Membrane / immunology,  microbiology
Nasal Mucosa / immunology
Th17 Cells / immunology*,  metabolism
Grant Support
ID/Acronym/Agency:
5R01HL061271/HL/NHLBI NIH HHS; DK6440/DK/NIDDK NIH HHS; P01 DK71176/DK/NIDDK NIH HHS; P30 DK072506/DK/NIDDK NIH HHS; P50 HL084932/HL/NHLBI NIH HHS; P50 HL084932-01/HL/NHLBI NIH HHS; P50HL084932/HL/NHLBI NIH HHS; R01 HL062052/HL/NHLBI NIH HHS; R21 HL104601/HL/NHLBI NIH HHS; R37 HL079142/HL/NHLBI NIH HHS; R37 HL079142/HL/NHLBI NIH HHS; R37 HL079142-06/HL/NHLBI NIH HHS; R37 HL079142-07/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Bacterial Outer Membrane Proteins; 0/Cytokines
Comments/Corrections
Comment In:
Immunity. 2011 Dec 23;35(6):854-6   [PMID:  22195742 ]

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