Document Detail

T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour.
MedLine Citation:
PMID:  23278668     Owner:  NLM     Status:  MEDLINE    
T helper type 17 (Th17) lymphocytes are found in high frequency in tumour-burdened animals and cancer patients. These lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, have a well-defined role in the development of inflammatory and autoimmune pathologies; however, their function in tumour immunity is less clear. We explored possible opposing anti-tumour and tumour-promoting functions of Th17 cells by evaluating tumour growth and the ability to promote tumour infiltration of myeloid-derived suppressor cells (MDSC), regulatory T cells and CD4(+)  interferon-γ(+) cells in a retinoic acid-like orphan receptor γt (RORγt) -deficient mouse model. A reduced percentage of Th17 cells in the tumour microenvironment in RORγt-deficient mice led to enhanced tumour growth, that could be reverted by adoptive transfer of Th17 cells. Differences in tumour growth were not associated with changes in the accumulation or suppressive function of MDSC and regulatory T cells but were related to a decrease in the proportion of CD4(+) T cells in the tumour. Our results suggest that Th17 cells do not affect the recruitment of immunosuppressive populations but favour the recruitment of effector Th1 cells to the tumour, thereby promoting anti-tumour responses.
Sarah Nuñez; Juan Jose Saez; Dominique Fernandez; Felipe Flores-Santibañez; Karla Alvarez; Gabriela Tejon; Paulina Ruiz; Paula Maldonado; Yessia Hidalgo; Valeria Manriquez; Maria Rosa Bono; Mario Rosemblatt; Daniela Sauma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunology     Volume:  139     ISSN:  1365-2567     ISO Abbreviation:  Immunology     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-09     Completed Date:  2013-06-07     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  England    
Other Details:
Languages:  eng     Pagination:  61-71     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
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MeSH Terms
Cell Line, Tumor
Immune Tolerance*
Mice, Mutant Strains
Neoplasms / genetics,  immunology*,  pathology
Nuclear Receptor Subfamily 1, Group F, Member 3 / genetics,  immunology
Th1 Cells / immunology*,  pathology
Th17 Cells / immunology*,  pathology
Reg. No./Substance:
0/Nuclear Receptor Subfamily 1, Group F, Member 3

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