| Th1 and th2 cytokine profiles in malignant pleural effusion. | |
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MedLine Citation:
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PMID: 22201616 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: The alteration of Th1 and Th2 cytokine levels is the subject of controversy in pleural effusions caused by malignancy, a situation that favors a Th2 immune response. Objective: To examine the different levels of IL-4 and IL-10 (Th2 cytokines), and IL-2 and interferon-γ (IFN-γ) (Th1 cytokines) in malignant and non-malignant pleural effusions. Method: The cytokine levels in pleural fluid of 62 patients with malignant pleural effusion (44 with lung cancer and 18 with extrathoracic tumors), 8 with tuberculous and 8 with congestive heart failure pleural effusion were analyzed using enzyme-linked immunosorbent assays. Results: IL-2 was below the detectable concentration of the assay. A significant decrease in IFN-γ level was observed in malignant but not in congestive heart failure cases compared to tuberculous cases. IL-10 levels were higher in malignant and tuberculous pleural effusions than in congestive heart failure pleural effusions, however, this difference did not reach the significant level. IL-4 levels were also increased non-significantly in lung cancer pleural effusions compared to the other groups. Conclusion: Our results show a wide variation in IL-4, IL-10, and IFN-γ levels in malignant pleural effusions, a pattern which was not convincing enough to differentiate the cause of effusion. |
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Authors:
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Mohammad Ali Ghayumi; Zahra Mojtahedi; Mohammad Javad Fattahi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Iranian journal of immunology : IJI Volume: 8 ISSN: 1735-1383 ISO Abbreviation: Iran J Immunol Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101282932 Medline TA: Iran J Immunol Country: Iran |
Other Details:
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Languages: eng Pagination: 195-200 Citation Subset: IM |
Affiliation:
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Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran, e-mail: mojtahediz@sums.ac.ir. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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