Document Detail

Th1 and Th2 in human IVF pregnancy with allogenic fetus.
MedLine Citation:
PMID:  18336389     Owner:  NLM     Status:  MEDLINE    
PROBLEM: Positive obstetric outcome of allogenic in vitro fertilization (IVF) pregnancies makes interesting the subject of additional regulatory mechanisms after oocyte donation. METHOD OF STUDY: Eighty eight women: 23 donation of oocytes (DO), 33 IVF, 32 natural conception (NC) were studied in first trimester of pregnancy. Intracellular production of cytokines and chemokine receptors expression were studied by flow cytometry. RESULTS: Intracellular production of interferon-gamma (IFN-gamma), interleukin (IL)-4, tumor necrosis factor-alpha by CD4 T lymphocytes in DO women was higher than in IVF and NC women. Ratio IFN-gamma/IL-4 in DO was lower than in IVF. We found higher expression of chemokine receptor CCR4 but not CXCR3 on CD4 T cells in DO compared with IVF and NC. Ratio CXCR3/CCR4 in DO was lower than in NC. CONCLUSION: Hyperactivation of T helper 1 (Th1) and T helper 2 (Th2) by allogenic fetus is specific for DO pregnancy. Preferable activation of Th2 and relative suppression of Th1 chemokine expression reflect additional regulatory counteractive mechanism(s).
Victor P Chernyshov; Larisa E Tumanova; Irina A Sudoma; Vladimir I Bannikov
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  59     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-13     Completed Date:  2008-06-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  352-8     Citation Subset:  IM    
Laboratory of Immunology, Institute of Pediatrics, Obstetrics and Gynecology, Academy of Medical Sciences, Kiev, Ukraine.
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MeSH Terms
B-Lymphocytes / immunology
Cytokines / biosynthesis,  metabolism
Embryo Transfer
Fertilization in Vitro*
Fetus / immunology*
Killer Cells, Natural / immunology
Oocyte Donation
Receptors, CXCR3 / metabolism
Receptors, CXCR4 / metabolism
Th1 Cells / immunology*,  metabolism
Th2 Cells / immunology*,  metabolism
Reg. No./Substance:
0/Cytokines; 0/Receptors, CXCR3; 0/Receptors, CXCR4

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