| Th1 and Th2 cytokine production is suppressed at the level of transcriptional regulation in Kawasaki disease. | |
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MedLine Citation:
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PMID: 15270865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To clarify the functional state of T cells in Kawasaki disease, we analysed mRNA expression levels of Th1/Th2 cytokines (IFN-gamma and IL-4) along with Th1/Th2-inducing transcription factors, T-bet and GATA-3, which play pivotal roles in the development of Th1 and Th2 cells, respectively. By real-time PCR, IFN-gamma mRNA levels in peripheral blood mononuclear cells (PBMNC) were significantly decreased in Kawasaki disease patients compared with those with measles, and tended to be lower than those in healthy controls. T-bet mRNA levels were significantly decreased in patients with Kawasaki disease compared with healthy controls. In addition, IL-4 and GATA-3 mRNA levels were significantly decreased in Kawasaki disease compared with healthy controls. Regulatory cytokine mRNA levels (TGF-beta and IL-10) were also decreased in Kawasaki disease. The mRNA levels of IFN-gamma showed a significant positive correlation with those of T-bet in Kawasaki disease. These results suggest that the suppressed function of Th1 and Th2, associated with the suppression of both T-bet and GATA-3 gene expression, may be one of the immunological characteristics of Kawasaki disease. |
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Authors:
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J Kimura; H Takada; A Nomura; T Ohno; Y Mizuno; M Saito; K Kusuhara; T Hara |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 137 ISSN: 0009-9104 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-07-23 Completed Date: 2004-09-20 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 444-9 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child Child, Preschool Cytokines / biosynthesis* Down-Regulation / immunology* GATA3 Transcription Factor Humans Infant Interferon-gamma / biosynthesis, genetics Interleukin-4 / biosynthesis, genetics Mucocutaneous Lymph Node Syndrome / immunology* RNA, Messenger / genetics T-Box Domain Proteins Th1 Cells / immunology* Th2 Cells / immunology* Transcription Factors / biosynthesis, genetics Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/GATA3 Transcription Factor; 0/GATA3 protein, human; 0/RNA, Messenger; 0/T-Box Domain Proteins; 0/T-box transcription factor TBX21; 0/Transcription Factors; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma |
| Comments/Corrections | |
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