Document Detail

Th-1 and Th-2 cytokine production in infants with virus-associated wheezing.
MedLine Citation:
PMID:  15665988     Owner:  NLM     Status:  MEDLINE    
Wheezing associated with respiratory viral infections in infancy is very common and results in high morbidity worldwide. The Th1/Th2 pattern of immune response in these patients remains unclear and previous studies have shown controversial results. The aim of the present study was to compare the type of Th1/Th2 cytokine response between infants with acute bronchiolitis, recurrent wheezing and upper respiratory infections from a developing country. Infants younger than 2 years of age admitted to Hospital São Lucas, Porto Alegre, RS, Brazil, between May and November 2001, with an acute episode of wheezing associated with viral respiratory infection were selected. Subjects with upper respiratory infections from the emergency department were selected for the control group. Interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) levels from nasal aspirates were determined by ELISA from peripheral mononuclear cell cultures. Twenty-nine subjects with acute bronchiolitis, 18 with recurrent wheezing and 15 with upper respiratory infections were enrolled. There were no differences in family history of atopy or parental smoking between groups. Oxygen requirement was similar for the acute bronchiolitis and recurrent wheezing groups. The percentage of positive tests for the cytokines studied and the IFN-gamma/IL-4 ratio was similar for all groups. Comparison of the polarized Th1/Th2 cytokine results for the various groups showed no specific pattern of cytokine production. Infants with wheezing from a developing country do not show any specific predominant pattern of Th1/Th2 cytokine production, suggesting that multiple factors may be involved in the pathogenesis of this illness.
P M C Pitrez; D C Machado; M H Jones; F Andrade; C Camozzato; R T Stein
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-01-18
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  38     ISSN:  0100-879X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-24     Completed Date:  2005-06-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  51-4     Citation Subset:  IM    
Laboratório de Pediatria e Neonatologia, Departamento de Pediatria, Instituto de Pesquisas Biomédicas, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
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MeSH Terms
Acute Disease
Bronchiolitis, Viral / immunology
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Interferon-gamma / biosynthesis*
Interleukin-4 / biosynthesis*
Nasal Lavage Fluid / chemistry,  microbiology
Respiratory Sounds / immunology*
Respiratory Tract Infections / immunology*,  virology
Th1 Cells / immunology*
Th2 Cells / immunology*
Virus Diseases / immunology
Reg. No./Substance:
207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma

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