Document Detail


TexMi: Development of Tissue-Engineered Textile-Reinforced Mitral Valve Prosthesis.
MedLine Citation:
PMID:  24665896     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Mitral valve regurgitation together with aortic stenosis is the most common valvular heart disease in Europe and North America. Mechanical and biological prostheses available for mitral valve replacement have significant limitations such as the need of a long-term anticoagulation therapy and failure by calcifications. Both types are unable to remodel, self-repair, and adapt to the changing hemodynamic conditions. Moreover, they are mostly designed for the aortic position and do not reproduce the native annular-ventricular continuity, resulting in suboptimal hemodynamics, limited durability, and gradually decreasing ventricular pumping efficiency. A tissue-engineered heart valve specifically designed for the mitral position has the potential to overcome the limitations of the commercially available substitutes. For this purpose, we developed the TexMi, a living textile-reinforced mitral valve, which recapitulates the key elements of the native one: annulus, asymmetric leaflets (anterior and posterior), and chordae tendineae to maintain the native annular-ventricular continuity. The tissue-engineered valve is based on a composite scaffold consisting of the fibrin gel as a cell carrier and a textile tubular structure with the twofold task of defining the gross three-dimensional (3D) geometry of the valve and conferring mechanical stability. The TexMi valves were molded with ovine umbilical vein cells and stimulated under dynamic conditions for 21 days in a custom-made bioreactor. Histological and immunohistological stainings showed remarkable tissue development with abundant aligned collagen fibers and elastin deposition. No cell-mediated tissue contraction occurred. This study presents the proof-of-principle for the realization of a tissue-engineered mitral valve with a simple and reliable injection molding process readily adaptable to the patient's anatomy and pathological situation by producing a patient-specific rapid prototyped mold.
Authors:
Ricardo Moreira; Valentine N Gesche; Luis G Hurtado-Aguilar; Thomas Schmitz-Rode; Julia Frese; Stefan Jockenhoevel; Petra Mela
Related Documents :
18065636 - Venous bullet embolism to the right ventricle.
24326586 - Echocardiographic assessment of the right heart in mice.
315876 - Mitral valve replacement in infective endocarditis as prophylaxis against embolism. ide...
7501376 - Intractable epistaxis: transantral ligation vs. embolization: efficacy review and cost ...
20824586 - Predictors for biventricular repair in pulmonary atresia with intact ventricular septum.
2252266 - Bilateral intrapulmonary hematomas.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-25
Journal Detail:
Title:  Tissue engineering. Part C, Methods     Volume:  -     ISSN:  1937-3392     ISO Abbreviation:  Tissue Eng Part C Methods     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101466663     Medline TA:  Tissue Eng Part C Methods     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Assessing the potential biological implications of recreational inshore fisheries on sub-tidal fish ...
Next Document:  Influence of the implant design on osseointegration and crestal bone resorption of immediate implant...