Document Detail

Tetrodotoxin prevents copper-induced bradycardia in gastropod limpets.
MedLine Citation:
PMID:  15993526     Owner:  NLM     Status:  MEDLINE    
Acute exposure to waterborne copper is followed by a reduction in heart rate in gastropod limpets. In order to understand the mechanism of this effect, exposure to copper (0.25 or 0.5 mg l(-1); for 3 and 6 h) was combined with an injection of tetrodotoxin (TTX, 20 microl, 0.5 or 1 microM), a natural toxin that inhibits the propagation and transmission of impulses in excitable tissues. Experiments were performed on the Mediterranean limpet Patella caerulea, using a non-invasive method for the recording of cardiac activity. TTX did not affect the bradycardic effect of the cholinergic agonist carbachol. However, this toxin significantly antagonized the bradycardia induced by 0.25 and 0.5mg l(-1) of copper exposure and prevented the acardia observed in some limpets exposed to 0.5mg l(-1) of copper for 6h. These results are consistent with the hypothesis that the inhibitory action of copper on limpet cardiac activity involves an extrinsic, cholinergic neuronal control.
Giada Bini; Anna Maria Pugliese; Giancarlo Pepeu; Guido Chelazzi
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Publication Detail:
Type:  Journal Article     Date:  2005-07-01
Journal Detail:
Title:  Environmental pollution (Barking, Essex : 1987)     Volume:  139     ISSN:  0269-7491     ISO Abbreviation:  Environ. Pollut.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-11-18     Completed Date:  2006-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804476     Medline TA:  Environ Pollut     Country:  England    
Other Details:
Languages:  eng     Pagination:  79-85     Citation Subset:  IM    
Department of Animal Biology and Genetics, University of Florence, 50125 Florence, Italy.
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MeSH Terms
Carbachol / pharmacology
Cholinergic Agonists / pharmacology
Copper / toxicity*
Dose-Response Relationship, Drug
Heart / drug effects,  physiology
Heart Rate / drug effects*
Mollusca / drug effects*,  physiology
Neural Pathways / drug effects,  physiology
Plethysmography / methods
Tetrodotoxin / pharmacology*
Water Pollutants, Chemical / toxicity*
Reg. No./Substance:
0/Cholinergic Agonists; 0/Water Pollutants, Chemical; 4368-28-9/Tetrodotoxin; 51-83-2/Carbachol; 7440-50-8/Copper

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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