Document Detail


Tetraspanin CD37 contributes to the initiation of cellular immunity by promoting dendritic cell migration.
MedLine Citation:
PMID:  23420539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies on the role of the tetraspanin CD37 in cellular immunity appear contradictory. In vitro approaches indicate a negative regulatory role, whereas in vivo studies suggest that CD37 is necessary for optimal cellular responses. To resolve this discrepancy, we studied the adaptive cellular immune responses of CD37(-/-) mice to intradermal challenge with either tumors or model antigens and found that CD37 is essential for optimal cell-mediated immunity. We provide evidence that an increased susceptibility to tumors observed in CD37(-/-) mice coincides with a striking failure to induce antigen-specific IFN-γ-secreting T cells. We also show that CD37 ablation impairs several aspects of DC function including: in vivo migration from skin to draining lymph nodes; chemo-tactic migration; integrin-mediated adhesion under flow; the ability to spread and form actin protrusions and in vivo priming of adoptively transferred naïve T cells. In addition, multiphoton microscopy-based assessment of dermal DC migration demonstrated a reduced rate of migration and increased randomness of DC migration in CD37(-/-) mice. Together, these studies are consistent with a model in which the cellular defect that underlies poor cellular immune induction in CD37(-/-) mice is impaired DC migration.
Authors:
Kate H Gartlan; Janet L Wee; Maria C Demaria; Roza Nastovska; Tsz Man Chang; Eleanor L Jones; Vasso Apostolopoulos; Geoffrey A Pietersz; Michael J Hickey; Annemiek B van Spriel; Mark D Wright
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-03-25
Journal Detail:
Title:  European journal of immunology     Volume:  43     ISSN:  1521-4141     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-25     Completed Date:  2013-06-17     Revised Date:  2013-10-29    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1208-19     Citation Subset:  IM    
Copyright Information:
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Department of Immunology, Monash University, Prahran, Victoria, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adaptive Immunity
Adoptive Transfer
Animals
Antigens, CD / genetics,  immunology*
Antigens, Neoplasm / genetics,  immunology*
Cell Adhesion / immunology
Cell Movement / immunology*
Cell Proliferation
Dendritic Cells / immunology*,  pathology
Female
Gene Expression
Immunity, Cellular*
Interferon-gamma / biosynthesis,  immunology
Lymph Nodes / immunology,  pathology
Lymphoma, T-Cell / genetics,  immunology,  pathology
Mice
Mice, Knockout
Microscopy, Confocal
Neoplasm Transplantation
Skin / immunology,  pathology
T-Lymphocytes / cytology,  immunology,  transplantation
Tetraspanins / deficiency,  genetics,  immunology*
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Neoplasm; 0/Cd37 protein, mouse; 0/Tetraspanins; 82115-62-6/Interferon-gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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