Document Detail

Tetraploidy, aneuploidy and cancer.
MedLine Citation:
PMID:  17324569     Owner:  NLM     Status:  MEDLINE    
Aneuploidy is one of the most obvious differences between normal and cancer cells. However, there remains debate over how aneuploid cells arise and whether or not they are a cause or consequence of tumorigenesis. One proposed route to aneuploid cancer cells is through an unstable tetraploid intermediate. Supporting this idea, recent studies demonstrate that tetraploidy promotes chromosomal aberrations and tumorigenesis in vivo. These tetraploid cells can arise by a variety of mechanisms, including mitotic slippage, cytokinesis failure, and viral-induced cell fusion. Furthermore, new studies suggest that there might not be a ploidy-sensing checkpoint that permanently blocks the proliferation of tetraploid cells. Therefore, abnormal division of tetraploid cells might facilitate genetic changes that lead to aneuploid cancers.
Neil J Ganem; Zuzana Storchova; David Pellman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2007-02-26
Journal Detail:
Title:  Current opinion in genetics & development     Volume:  17     ISSN:  0959-437X     ISO Abbreviation:  Curr. Opin. Genet. Dev.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-16     Completed Date:  2007-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111375     Medline TA:  Curr Opin Genet Dev     Country:  England    
Other Details:
Languages:  eng     Pagination:  157-62     Citation Subset:  IM    
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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MeSH Terms
Cell Proliferation*
DNA Replication*
Genomic Instability / genetics
Models, Genetic*
Neoplasms / genetics*
Tumor Suppressor Protein p53 / metabolism
Grant Support
Reg. No./Substance:
0/Tumor Suppressor Protein p53

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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