| Tetraoxanes: synthetic and medicinal chemistry perspective. | |
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MedLine Citation:
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PMID: 21064188 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The discovery of artemisinin from Chinese medicinal plant, Artemisia annua in 1971, opened a new era in the malarial chemotherapy. This discovery was the beginning of exploring peroxides as potential replacements for the traditional antimalarial drugs such as chloroquine and mefloquine. The structurally simple class of peroxides that emerged from these studies was the 1,2,4,5-tetraoxanes. This study describes the current status of tetraoxane-based antimalarials that show significant promises because of their artemisinin-like activity. Literature from 1999 has been critically reviewed and an attempt has been made to discuss various synthetic methods and structure-activity relationship study among the series of tetraoxane-based compounds. © 2010 Wiley Periodicals, Inc. Med Res Rev. |
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Authors:
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Nitin Kumar; Ram Singh; Diwan S Rawat |
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Publication Detail:
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Type: Journal Article; Retracted Publication Date: 2010-11-09 |
Journal Detail:
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Title: Medicinal research reviews Volume: - ISSN: 1098-1128 ISO Abbreviation: Med Res Rev Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2011-05-24 Completed Date: 2011-05-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8103150 Medline TA: Med Res Rev Country: United States |
Other Details:
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Languages: eng Pagination: - Citation Subset: - |
Affiliation:
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Department of Chemistry, University of Delhi, Delhi-110007, India. |
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| Comments/Corrections | |
Retraction In:
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Med Res Rev. 2011 May;31(3):482
[PMID:
20027667
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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