Document Detail

Tetralogy of fallot: yesterday and today.
MedLine Citation:
PMID:  20091166     Owner:  NLM     Status:  MEDLINE    
Tetralogy of Fallot (TOF) is a cyanotic congenital cardiac defect that was first described by Stenson in 1672 and later named for Fallot, who in 1888 described it as a single pathological process responsible for (1) pulmonary outflow tract obstruction, (2) ventricular septal defect (VSD), (3) overriding aortic root, and (4) right ventricular hypertrophy. The surgical history of TOF began with the development of the systemic to pulmonary artery shunt (BT shunt) by Blalock, Taussig, and Thomas in 1944. Ten years later complete repair of TOF was performed by Lillehei using cross-circulation and by Kirklin with a primitive cardiopulmonary bypass circuit. Notable contributions by several other surgeons including Bahnson, Ebert, Malm, Trusler, Barratt-Boyes, and Castaneda would lead us into the modern era of surgery. Today, complete repair of TOF is performed before six months of age with low mortality (<2%). In select cases a modified version of the BT shunt is still performed as the initial procedure. Long-term survival rates are excellent (85%-90%). Adult survivors with TOF are an ever-increasing population and may require reintervention, surgically or catheter based. Promising future innovations include percutaneous pulmonary valve replacement, tissue-engineered autologous valves and conduits, and genetic manipulation. This article presents a review of TOF, including the history of surgical treatment, present-day approaches, and long-term outcomes.
Joanne P Starr
Related Documents :
6700216 - Creation of left-to-right shunts in the newborn pig: a new model.
2996576 - Quantification of intracardiac shunts by gold-195m, a new radionuclide with a short hal...
19136756 - Superior vena cava syndrome after pulsatile bidirectional glenn shunt procedure: periop...
12758116 - Spinal cord arteriovenous shunts: from imaging to management.
20337246 - Unstable angina clue to coronary artery muscle bridge: a case report.
18948876 - Surgical treatment of celiac artery aneurysm associated with median arcuate ligament.
Publication Detail:
Type:  Historical Article; Journal Article; Review    
Journal Detail:
Title:  World journal of surgery     Volume:  34     ISSN:  1432-2323     ISO Abbreviation:  World J Surg     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-05     Completed Date:  2010-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704052     Medline TA:  World J Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  658-68     Citation Subset:  IM    
Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, NJ, 07103, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Factors
Cardiac Surgical Procedures / history*
History, 20th Century
History, 21st Century
Tetralogy of Fallot / history*,  surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  No survival difference after successful (131)I ablation between patients with initially low-risk and...
Next Document:  Mammographic determination of breast volume by elliptical cone estimation.