| Tetrahydroxystilbene glucoside attenuates MPP+-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation. | |
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MedLine Citation:
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PMID: 20643188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is known that oxidative stress plays a major role in the progression of Parkinson's disease (PD). Previous studies have suggested that 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside (TSG), an active component extracted from a traditional Chinese herb Polygonum multiflorum Thunb., has significant antioxidant and free radical-scavenging activities. This is the first study that investigated the protective effects of TSG against MPP(+)-induced apoptosis in PC12 cells and determined the underlying mechanism. The results showed that incubation of PC12 cells with TSG before exposing them to MPP(+) could significantly decrease cell viability loss and reverse cell apoptosis in a dose-dependent manner. The anti-apoptotic effects of TSG were probably mediated via the inhibition of ROS generation and modulation of JNK activation because TSG blocked ROS increase and JNK phosphorylation induced by MPP(+). Taken together, these results indicated that TSG may provide a useful therapeutic strategy for the treatment of neurodegenerative diseases such as PD. |
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Authors:
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Xiaobing Li; Yan Li; Jianzong Chen; Jing Sun; Xiaofeng Li; Xin Sun; Xiaogang Kang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-17 |
Journal Detail:
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Title: Neuroscience letters Volume: 483 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-12-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 1-5 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Research Center of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, No 17 Changlexi Road, Xi'an 710032, People's Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Methyl-4-phenylpyridinium
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pharmacology* Analysis of Variance Animals Apoptosis / drug effects* Blotting, Western Cell Count Cell Survival / drug effects* Cells, Cultured Dose-Response Relationship, Drug Flow Cytometry Glucosides / pharmacology* PC12 Cells Rats Reactive Oxygen Species / metabolism* Stilbenes / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/2',3',4',5'-tetrahydroxystilbene-2-O-beta-D-glucoside; 0/Glucosides; 0/Reactive Oxygen Species; 0/Stilbenes; 48134-75-4/1-Methyl-4-phenylpyridinium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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