Document Detail


Tetrahydrobiopterin supplementation enhances carotid artery compliance in healthy older men: a pilot study.
MedLine Citation:
PMID:  22673017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: We performed a pilot study to test the hypothesis that acute oral ingestion of tetrahydrobiopterin (BH(4)), a key cofactor modulating vascular nitric oxide (NO) synthase activity, improves large elastic artery stiffness with aging in men.
METHODS: Healthy older (63 ± 2 years; n = 8) and young (age 25 ± 1 years; n = 6) men were studied 3 h after ingestion of BH(4) (10 mg·kg(-1) body weight) or placebo on separate days in a randomized, placebo-controlled, double-blind study.
RESULTS: Baseline carotid artery compliance was 37% lower (0.17 ± 0.02 vs. 0.22 ± 0.02 mm/mm Hg·10(-1)) and β-stiffness was 42% higher (7.3 ± 1.1 vs. 4.2 ± 0.5 AU) in the older men (both P < 0.05). BH(4) ingestion markedly increased circulating BH(4) concentrations in both groups (17-19-fold, P < 0.05), but increased compliance (+39% to 0.23 ± 0.02 mm/mm Hg·10(-1), P < 0.01) and decreased β-stiffness index (-27% to 5.3 ± 0.7 AU, P < 0.01) only in the older men. BH(4) also reduced carotid systolic blood pressure (SBP) in the older men (P < 0.05).
CONCLUSIONS: These preliminary results support the possibility that limited BH(4) bioavailability contributes to impaired carotid artery compliance in healthy older men. Further studies are needed to determine if increasing BH(4) bioavailability though oral BH(4) supplementation may have therapeutic efficacy for improving large elastic artery compliance and reducing central SBP with aging.
Authors:
Gary L Pierce; Kristen L Jablonski; Ashley E Walker; Sara Marian Seibert; Allison E DeVan; Stephen M Black; Shruti Sharma; Douglas R Seals
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-06-07
Journal Detail:
Title:  American journal of hypertension     Volume:  25     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-20     Completed Date:  2013-02-01     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1050-4     Citation Subset:  IM    
Affiliation:
Department of Integrative Physiology, University of Colorado, Boulder, USA. gary-pierce@uiowa.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biopterin / analogs & derivatives*,  pharmacology
Carotid Arteries / drug effects,  physiology*
Compliance / drug effects
Dietary Supplements
Double-Blind Method
Humans
Male
Middle Aged
Pilot Projects
Vascular Stiffness / drug effects
Grant Support
ID/Acronym/Agency:
AG000279/AG/NIA NIH HHS; AG013038/AG/NIA NIH HHS; AG033994/AG/NIA NIH HHS; F31 AG033994/AG/NIA NIH HHS; R37 AG013038/AG/NIA NIH HHS; UL1 RR025780/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
17528-72-2/5,6,7,8-tetrahydrobiopterin; 22150-76-1/Biopterin
Comments/Corrections
Comment In:
Am J Hypertens. 2013 Apr;26(4):580   [PMID:  23467213 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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