| Tetraethylammonium-induced phasic arterial constriction: temporal and spatial characteristics. | |
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MedLine Citation:
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PMID: 3740296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In vitro techniques were developed to characterize temporal, spatial, and mechanical characteristics of tetraethylammonium (TEA)-induced phasic contractile activity in pressurized perfused canine femoral artery segments. Power spectral analysis revealed TEA-induced phasic activity to be included in the bandwidth from 0.004 to 0.016 Hz. The level of intraluminal pressure did not influence frequency characteristics of this activity. Mean total tangential stress increased proportionately with intraluminal pressure, whereas both mean developed tangential stress and the strain index mean percent change of external diameter showed a plateau in the 80- to 120-mmHg pressure range. TEA-induced phasic activity propagated longitudinally in all arteries studied. The velocity of longitudinal propagation (V, cm/s) varied with intraluminal pressure in a nonlinear fashion with V = 0.79 +/- 0.05 at 40 mmHg, V = 0.72 +/- 0.05 at 80 mm Hg, and V = 0.85 +/- 0.05 at 120 mmHg. V was not affected by tetrodotoxin, and phasic activity was abolished by verapamil. Phasic activity showed a primary direction of propagation 81 +/- 7% of the time; however, this direction was variable in all arteries. Thus vascular smooth muscle activation by TEA, which has been proposed as a model for coronary artery spasm, produces propagated constrictor responses in the ultra-low-frequency band with pressure-sensitive velocity characteristics and mechanical properties that are optimized in the physiological pressure range. |
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Authors:
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C R Lambert; C J Pepine |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of physiology Volume: 251 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1986 Aug |
Date Detail:
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Created Date: 1986-09-17 Completed Date: 1986-09-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H436-42 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Femoral Artery / drug effects* Physiology / instrumentation Tetraethylammonium Tetraethylammonium Compounds / pharmacology* Time Factors Vasoconstriction* Verapamil / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Tetraethylammonium Compounds; 52-53-9/Verapamil; 66-40-0/Tetraethylammonium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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