Document Detail

Tetracycline actions relevant to rosacea treatment.
MedLine Citation:
PMID:  19786821     Owner:  NLM     Status:  MEDLINE    
Until today, the pathogenesis of rosacea is not known in detail. Yet in recent years evidence has been accumulating that rosacea with its common symptoms such as inflammatory lesions, erythema, telangiectasia, phymatous changes, and ocular symptoms is of inflammatory nature. Tetracycline derivatives like doxycycline successfully used in the treatment of skin diseases like acne and rosacea seem to inhibit different inflammatory pathways involved in the pathogenesis by various modes of action. Although data for skin diseases are relatively scanty, the following modes of action of tetracyclines seem to be most relevant for an effective treatment of acne and rosacea: inhibition of matrix metalloproteinases, downmodulation of cytokines, inhibition of cell movement and proliferation, inhibition of granuloma formation, inhibition of reactive oxygen species, nitric oxide, and angiogenesis, whereas inhibition of phospholipase A2 seems to be of lower importance. The role of the saprophytic mite Demodex folliculorum remains to be clarified. Additional studies are necessary to further elucidate how tetracyclines work in rosacea treatment.
H C Korting; C Sch??llmann
Publication Detail:
Type:  Journal Article; Review     Date:  2009-09-25
Journal Detail:
Title:  Skin pharmacology and physiology     Volume:  22     ISSN:  1660-5535     ISO Abbreviation:  Skin Pharmacol Physiol     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-20     Completed Date:  2010-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101188418     Medline TA:  Skin Pharmacol Physiol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  287-94     Citation Subset:  IM    
Department of Dermatology and Allergology, Ludwig-Maximilians-Universit??t, Munich, Germany.
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MeSH Terms
Doxycycline / pharmacology,  therapeutic use
Inflammation / drug therapy,  physiopathology*
Mite Infestations / physiopathology
Rosacea / drug therapy*,  physiopathology
Tetracyclines / pharmacology,  therapeutic use*
Reg. No./Substance:
0/Tetracyclines; 564-25-0/Doxycycline

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