Document Detail

Tetracycline and 13-cis-retinoic acid inhibit production and activity of granulocyte activating factor (GAF) from Propionibacterium acnes.
MedLine Citation:
PMID:  1698375     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate different treatment schedules on release or activity of a granulocyte activating factor (GAF) from Propionibacterium acnes. Incubation of P. acnes in physiological saline (30 min, 37 degrees C) resulted in release of a soluble factor that elicited considerable chemiluminescence response and chemotactic stimulus on human granulocytes. Pretreatment of the microorganisms with subinhibitory concentrations of tetracycline or incubation of granulocytes with 13-cis-retinoic acid significantly reduced the activating potency of GAF on these phagocytic cells. Since GAF was considered to be one of the stimuli for inflammation in acne vulgaris, administration of tetracycline and 13-cis-retinoic acid appears to be an adequate therapy.
G Pulverer; H L Ko; J Beuth; W Roszkowski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zentralblatt für Bakteriologie : international journal of medical microbiology     Volume:  273     ISSN:  0934-8840     ISO Abbreviation:  Zentralbl. Bakteriol.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-11-14     Completed Date:  1990-11-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203851     Medline TA:  Zentralbl Bakteriol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  362-8     Citation Subset:  IM    
Institute of Medical Microbiology and Hygiene, University of Cologne.
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MeSH Terms
Chemotaxis, Leukocyte
Granulocyte Colony-Stimulating Factor / antagonists & inhibitors*,  biosynthesis
Granulocytes / immunology
Luminescent Measurements
Propionibacterium acnes / drug effects*,  immunology
Tetracycline / pharmacology*
Tretinoin / pharmacology*
Reg. No./Substance:
143011-72-7/Granulocyte Colony-Stimulating Factor; 302-79-4/Tretinoin; 60-54-8/Tetracycline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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