Document Detail


Tetracalcium phosphate composite containing quaternary ammonium dimethacrylate with antibacterial properties.
MedLine Citation:
PMID:  22190356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tooth caries is a carbohydrate-modified bacterial infectious disease, and recurrent caries is a frequent reason for restoration failure. The objective of this study was to develop a novel antibacterial composite using tetracalcium phosphate (TTCP) fillers and bis(2-methacryloyloxy-ethyl) dimethyl-ammonium bromide, which is a quaternary ammonium dimethacrylate (QADM). QADM was synthesized using 2-(N,N-dimethylamino)ethyl methacrylate and 2-bromoethyl methacrylate and incorporated into a resin. The resin was filled with 40% TTCP and 30% glass particles. The following QADM mass fractions in the composite were tested: 0%, 6%, 12%, and 18%. Streptococcus mutans biofilms were formed on the composites and the colony-forming units (CFUs), metabolic activity, and lactic acid production were measured. The TTCP-QADM composite had flexural strength and elastic modulus similar to those of two commercial composites (p > 0.1). Increasing the QADM content in TTCP composite greatly decreased the bacteria growth and biofilm matrix production. There were significantly more dead bacteria with increasing QADM content. TTCP composite containing 18% QADM had biofilm CFU, metabolic activity, and acid production about half of those without QADM. Inversely linear relationships were established between QADM mass fraction and S. mutans biofilm CFU, metabolic activity, and acid production, with correlation coefficients R(2) ≥ 0.98. In conclusion, TTCP-QADM composites were developed and the effect of QADM mass fraction on the antibacterial properties of the composite was determined for the first time. The novel TTCP-QADM composites possessing a strong antibacterial capability, together with calcium phosphate ion release and good mechanical properties, are promising for dental restorations to reduce biofilm growth and recurrent caries.
Authors:
Lei Cheng; Michael D Weir; Penwadee Limkangwalmongkol; Gary D Hack; Hockin H K Xu; Qianming Chen; Xuedong Zhou
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-12-21
Journal Detail:
Title:  Journal of biomedical materials research. Part B, Applied biomaterials     Volume:  100     ISSN:  1552-4981     ISO Abbreviation:  J. Biomed. Mater. Res. Part B Appl. Biomater.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-02     Completed Date:  2012-07-02     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101234238     Medline TA:  J Biomed Mater Res B Appl Biomater     Country:  United States    
Other Details:
Languages:  eng     Pagination:  726-34     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
Affiliation:
Biomaterials and Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, Maryland 21201, USA.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / chemistry*
Biofilms / growth & development*
Calcium Phosphates / chemistry*
Composite Resins* / chemical synthesis,  chemistry
Dental Caries / microbiology,  prevention & control
Glass / chemistry*
Humans
Methacrylates / chemistry*
Streptococcus mutans / physiology*
Grant Support
ID/Acronym/Agency:
R01 DE017974/DE/NIDCR NIH HHS; R01 DE14190/DE/NIDCR NIH HHS; R01 DE17974/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Calcium Phosphates; 0/Composite Resins; 0/Methacrylates; 0/tetracalcium phosphate
Comments/Corrections

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