Document Detail


Tetrabenazine fails to antagonize a behavioral effect of cocaine in rhesus monkeys.
MedLine Citation:
PMID:  11812502     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
For research and therapeutic purposes, a cocaine antagonist is an important drug development goal. The vesicular monoamine transport inhibitor tetrabenazine was tested for interaction with cocaine using food-reinforced responding in rhesus monkeys as an assay. Both tetrabenazine and cocaine suppressed food-maintained behavior individually. However, a low-dose tetrabenazine pretreatment did not alter the rate-suppressing effects of cocaine and cocaine did not alter the rate-suppressing effects of a high dose tetrabenazine pretreatment. Because tetrabenazine interacts with the monoamine oxidase inhibitor deprenyl in this assay, we conclude that cocaine does not produce an effect through vesicular catecholamines in this assay.
Authors:
Lee Koetzner; Tina L Sumpter; James H Woods
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  71     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:    2002 Jan-Feb
Date Detail:
Created Date:  2002-01-28     Completed Date:  2002-04-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Michigan, 1301 MSRB III/1150 West Medical Center Drive, Ann Arbor, MI 48109-0632, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic Uptake Inhibitors / pharmacology*
Animals
Behavior, Animal / drug effects*,  physiology
Cocaine / antagonists & inhibitors*,  pharmacology*
Conditioning, Operant / drug effects,  physiology
Dopamine Uptake Inhibitors / antagonists & inhibitors*,  pharmacology*
Drug Interactions / physiology
Female
Macaca mulatta
Male
Reaction Time / drug effects,  physiology
Tetrabenazine / pharmacology*
Grant Support
ID/Acronym/Agency:
DA00254/DA/NIDA NIH HHS; F31DA05777/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic Uptake Inhibitors; 0/Dopamine Uptake Inhibitors; 50-36-2/Cocaine; 58-46-8/Tetrabenazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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