Document Detail


Tetomilast: new promise for phosphodiesterase-4 inhibitors?
MedLine Citation:
PMID:  23043390     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Tetomilast is a novel thiazole phosphodiesterase-4 (PDE-4) inhibitor, which may prove useful in both the treatment of inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD). Here, the authors review the pharmacology of the drug, and offer critical review of the available data for use of tetomilast in the treatment of IBD.
AREAS COVERED: Peer-reviewed publications, including Phase I and II clinical trials, all other formats included.
EXPERT OPINION: Tetomilast may be beneficial in IBD. Small differences in molecules and in recombinant proteins can translate into substantial differences in clinical effects and toxicity in IBD. This is a reasonable approach when exploring new options like tetomilast.
Authors:
Stephen J Bickston; Kenneth R Snider; Matthew R Kappus
Publication Detail:
Type:  Journal Article; Review     Date:  2012-10-08
Journal Detail:
Title:  Expert opinion on investigational drugs     Volume:  21     ISSN:  1744-7658     ISO Abbreviation:  Expert Opin Investig Drugs     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-09     Completed Date:  2013-04-18     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9434197     Medline TA:  Expert Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  1845-9     Citation Subset:  IM    
Affiliation:
Virginia Commonwealth University Medical Center, VCUHS Center for Inflammatory Bowel Disease, MCV Campus, Box 980341, Richmond, VA 23298-0341, USA. sbickston@mcvh-vcu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents / pharmacology,  therapeutic use*
Humans
Inflammatory Bowel Diseases / drug therapy*
Phosphodiesterase 4 Inhibitors / pharmacology,  therapeutic use*
Thiazoles / pharmacology,  therapeutic use*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Phosphodiesterase 4 Inhibitors; 0/Thiazoles; S6RXB5KF56/tetomilast

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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