Document Detail

Tetany in kala azar patients treated with paromomycin.
MedLine Citation:
PMID:  18653914     Owner:  NLM     Status:  MEDLINE    
Paromomycin, an aminoglycoside, is known to cause several side effects like nephrotoxicity and ototoxicity like other aminoglycosides but tetany has not been reported. Three cases of tetany were detected in the patients of kala-azar treated with paromomycin. They were promptly treated with intravenous 10 per cent calcium gluconate and tetany was relieved immediately and treatment with paromomycin continued with oral calcium supplement. After completion of 21 days treatment with paromomycin patients' splenic aspirates were free of parasites. Paromomycin may cause temporary tubular damage leading to calcium wasting in urine and hypocalcaemia resulting in tetany. Prompt detection of symptoms and intravenous calcium gluconate treatment promptly reverse the situation.
C P Thakur
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Indian journal of medical research     Volume:  127     ISSN:  0971-5916     ISO Abbreviation:  Indian J. Med. Res.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-07-25     Completed Date:  2008-11-10     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0374701     Medline TA:  Indian J Med Res     Country:  India    
Other Details:
Languages:  eng     Pagination:  489-93     Citation Subset:  IM    
Balaji Utthan Sansthan, Patna, India.
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MeSH Terms
Anti-Bacterial Agents* / adverse effects,  therapeutic use
Calcium / metabolism
Child, Preschool
Leishmaniasis, Visceral / drug therapy*
Paromomycin* / adverse effects,  therapeutic use
Randomized Controlled Trials as Topic
Tetany / chemically induced*
Reg. No./Substance:
0/Anti-Bacterial Agents; 7440-70-2/Calcium; 7542-37-2/Paromomycin

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