| Testosterone and type 2 diabetes. | |
| | |
MedLine Citation:
|
PMID: 20418720 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE OF REVIEW: To describe the relationship between testosterone levels and type 2 diabetes (T2D). RECENT FINDINGS: Multiple epidemiological studies have shown that low testosterone levels are associated with and predict the future development of T2D and the metabolic syndrome. Although this relationship is confounded by the association of total testosterone with sex hormone-binding globulin, free testosterone remains associated with measures of insulin resistance and T2D in some, but not all studies. Although the link between low testosterone levels and insulin resistance is not solely a consequence of adiposity, current studies suggest that a substantial component is mediated through its association with body fat, in particular abdominal visceral adipose tissue. This testosterone-fat relationship is bi-directional, as both weight loss and testosterone therapy increase testosterone levels, reduce fat mass, and decrease insulin resistance. SUMMARY: Low testosterone levels are very commonly found in men with T2D and are associated with aging and obesity. Whether testosterone treatment in men with T2D decreases insulin resistance above that attributable to its fat-reducing effect is currently unknown. Future studies should compare testosterone treatment with lifestyle changes (exercise and weight loss measures), and other insulin-sensitizing agents. Until further evidence is available, testosterone therapy outside clinical trials should be reserved for diabetic men with unequivocal hypogonadism. |
| | |
Authors:
|
Mathis Grossmann; Emily J Gianatti; Jeffrey D Zajac |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Current opinion in endocrinology, diabetes, and obesity Volume: 17 ISSN: 1752-2978 ISO Abbreviation: Curr Opin Endocrinol Diabetes Obes Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-04-26 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101308636 Medline TA: Curr Opin Endocrinol Diabetes Obes Country: England |
Other Details:
|
Languages: eng Pagination: 247-56 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Austin Health/Northern Health, University of Melbourne, Heidelberg, Victoria, Australia. mathisg@unimelb.edu.au |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adiposity
/
physiology Aging / physiology Diabetes Mellitus, Type 2 / physiopathology* Humans Insulin Resistance / physiology Male Metabolic Syndrome X / physiopathology Sex Hormone-Binding Globulin / physiology Testosterone / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Sex Hormone-Binding Globulin; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Androgens and obesity.
Next Document: Immunologic and virologic predictors of AIDS-related non-hodgkin lymphoma in the highly active antir...