| Testosterone therapy for postmenopausal women: efficacy and safety. | |
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MedLine Citation:
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PMID: 16633985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The treatment of postmenopausal women with a variety of androgen formulations is increasing, despite the lack of clear guidelines regarding the diagnosis of androgen insufficiency. This review summarizes evidence on the efficacy and safety of adding testosterone to hormone therapy in postmenopausal women. Fair to good evidence exists that the use of testosterone in combination with hormone therapy has both benefits and risks. The benefits are an improvement in sexual function with various regimens of testosterone use (good evidence), an improved sense of well-being with transdermal testosterone (fair evidence), and a reduction in triglyceride levels with methyl testosterone (fair evidence). The most consistent risk is a reduction in high-density lipoprotein (HDL) cholesterol, particularly with methyl testosterone (good evidence). There has been insufficient reporting of other side effects; hence, testosterone therapy should be used with caution. The use of testosterone may be justified in specific clinical circumstances and should be limited to short-term use; long-term studies are not available. Close surveillance for HDL cholesterol and other side effects is necessary. |
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Authors:
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Woraluk Somboonporn |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in reproductive medicine Volume: 24 ISSN: 1526-8004 ISO Abbreviation: Semin. Reprod. Med. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-04-24 Completed Date: 2006-06-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100909394 Medline TA: Semin Reprod Med Country: United States |
Other Details:
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Languages: eng Pagination: 115-24 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. wsomboonporn@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Androgens
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deficiency Body Composition Bone and Bones / physiology Breast Neoplasms Cardiovascular Diseases Cholesterol, HDL / blood Cognition Estrogen Replacement Therapy Fatigue Female Humans Libido Postmenopause* Risk Factors Sexual Dysfunction, Physiological / drug therapy Testosterone / administration & dosage, adverse effects*, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 0/Cholesterol, HDL; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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