Document Detail


Testosterone therapy during exercise rehabilitation in male patients with chronic heart failure who have low testosterone status: a double-blind randomized controlled feasibility study.
MedLine Citation:
PMID:  23194490     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: This study assessed the feasibility of a 12-week program of exercise, with and without intramuscular testosterone supplementation, in male patients with chronic heart failure (CHF) and low testosterone status and collected preliminary data for key health outcomes.
METHODS: Male patients with CHF (n = 41, age 67.2 years, range 51-84 years) with mean ± SD testosterone levels of 10.7 ± 2.6 nmol/L (309 ± 76 ng/dL) were randomly allocated to exercise with testosterone or placebo groups. Feasibility was assessed in terms of recruitment, intervention compliance, and attrition. Outcomes included an incremental shuttle walk test, peak oxygen uptake, muscular strength, echocardiographic measures, N-terminal pro-brain natriuretic peptide, inflammatory markers, depression (Beck Depression Inventory), and health-related quality of life (Minnesota Living with Heart Failure Questionnaire and Medical Outcomes Study Short-Form).
RESULTS: Attrition was 30% but with 100% compliance to exercise and injections in patients who completed the study. Similar improvements in shuttle walk test (18% vs 19%), body mass (-1.3 kg vs -1.0 kg), and hand grip strength (2.1 kg vs 2.5 kg) from baseline were observed in both groups. The exercise with testosterone group showed improvements from baseline in peak oxygen uptake (P < .01), Beck Depression Inventory (P < .05), leg strength (P < .05), and several Medical Outcomes Study Short-Form quality of life domains (P < .05), which were generally not apparent in the exercise with placebo group. Echocardiographic measures, N-terminal pro-brain natriuretic peptide, and inflammatory markers were mostly unchanged.
CONCLUSIONS: This study shows for the first time that testosterone supplementation during a program of exercise rehabilitation is feasible and can positively impact on a range of key health outcomes in elderly male patients with CHF who have a low testosterone status.
Authors:
Martin Stout; Garry A Tew; Helen Doll; Irena Zwierska; Nicola Woodroofe; Kevin S Channer; John M Saxton
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-10-30
Journal Detail:
Title:  American heart journal     Volume:  164     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  2013-02-12     Revised Date:  2014-03-27    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  893-901     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Data Bank Information
Bank Name/Acc. No.:
ISRCTN/ISRCTN99667121
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Androgens / administration & dosage*
Body Mass Index
Chronic Disease
Cohort Studies
Combined Modality Therapy
Depression
Double-Blind Method
Echocardiography
Exercise Test
Exercise Therapy*
Feasibility Studies
Great Britain
Heart Failure / blood,  therapy*
Humans
Male
Middle Aged
Muscle Strength
Quality of Life
Testosterone / administration & dosage*,  blood
Treatment Outcome
Chemical
Reg. No./Substance:
0/Androgens; 3XMK78S47O/Testosterone
Comments/Corrections
Comment In:
J Urol. 2014 Mar;191(3):750-1   [PMID:  24522059 ]
Am Heart J. 2013 Oct;166(4):e21   [PMID:  24093863 ]
Am Heart J. 2013 Oct;166(4):e23   [PMID:  24093864 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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