| Testosterone therapy decreased subcutaneous fat and adiponectin in ageing men. | |
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MedLine Citation:
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PMID: 22190001 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: Testosterone therapy increases lean body mass (LBM) and decreases total fat mass (TFM) in ageing men with low normal testosterone levels. The major challenge is, however, to determine whether the metabolic consequences of testosterone therapy are overall positive. We have previously reported that six months testosterone therapy did not improve insulin sensitivity. We investigated the effect of testosterone therapy on regional body fat distribution and the levels of the insulin sensitizing adipokine, adiponectin, in ageing men with low normal bioavailable testosterone levels.Design: A randomized, double-blinded, placebo-controlled study of six months testosterone treatment (gel) in 38 men, aged 60-78 years, with bioavailable testosterone < 7.3 nmol/l and a waist circumference > 94 cm. Methods: Central fat mass (CFM) and lower extremity fat mass (LEFM) were measured by dual x-ray absorptiometry (DXA). Subcutaneous abdominal adipose tissue (SAT), visceral adipose tissue (VAT) and thigh subcutaneous fat area (TFA) were measured by magnetic resonance imaging (MRI). Adiponectin levels were measured using an in-house immunofluorometric assay. Coefficients (b) represent the placebo-controlled mean effect of intervention.Results: LEFM was decreased (b=-0.47 kg, p=0.07) while CFM did not change significantly (b=-0.66 kg, p=0.10) during testosterone therapy. SAT (b=-3.0 %, p=0.018) and TFA (b=-3.0 %, p<0.001) decreased, while VAT (b=1.0 %; p=0.54) remained unchanged. Adiponectin levels decreased during testosterone therapy (b=-1.3 mg/l, p=0.001).Conclusion: Our data showed that testosterone therapy decreased subcutaneous fat on the abdomen and lower extremities, but had no significant effect on visceral fat. Moreover, adiponectin levels were significantly decreased during testosterone therapy. |
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Authors:
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Louise Frederiksen; Kurt Hojlund; David M Hougaard; Thomas H Mosbech; Rasmus Larsen; Allan Flyvbjerg; Jan Frystyk; Kim Brixen; Marianne Andersen |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-21 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: - ISSN: 1479-683X ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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L Frederiksen, Endocrinology, Odense University Hospital, Odense, Denmark. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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