| Testosterone supplementation: why and for whom? | |
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MedLine Citation:
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PMID: 14628499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Androgen levels decline over a man's lifetime. In a proportion of men (increasing with age), levels fall below values that have been established by conventional laboratory criteria as indicative of hypogonadism. Testosterone has a wide range of non-reproductive actions: it preserves bone and muscle mass, it acts on non-sexual mental functioning and it stimulates red blood cell formation. Long-term androgen deficiency has a great impact on quality of life. The first intervention studies provide indications that androgen treatment of men with true androgen deficiency is helpful. Obviously, only men who are testosterone-deficient will benefit from androgen supplementation. The diagnosis of testosterone deficiency in old age is not unambiguous. Signs and symptoms of aging sometimes clinically overlap with those of testosterone deficiency. The groups that are at higher risk of testosterone deficiency are those men with disease (pulmonary disease, gastro-intestinal disease, rheumatoid disease, etc.). Usually, sex hormone binding globulin levels increase with aging, leading to lower levels of free, biologically available testosterone. For the time being, arbitrary criteria for testosterone deficiency in aging men have to be adopted. The best practical approach is to calculate the free testosterone level. The calculation can be found at www.issam.ch under 'Tools'. |
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Authors:
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L Gooren |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The aging male : the official journal of the International Society for the Study of the Aging Male Volume: 6 ISSN: 1368-5538 ISO Abbreviation: Aging Male Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-11-21 Completed Date: 2004-01-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9808210 Medline TA: Aging Male Country: United States |
Other Details:
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Languages: eng Pagination: 184-99 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, Vrije Universiteit Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aging / physiology Androgens / administration & dosage*, blood, deficiency Body Composition Bone Density Cardiovascular Diseases / chemically induced, prevention & control Hormone Replacement Therapy* Humans Male Middle Aged Patient Selection Testosterone / administration & dosage*, blood, deficiency |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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