Document Detail

Testosterone replacement therapy: current trends and future directions.
MedLine Citation:
PMID:  15297434     Owner:  NLM     Status:  MEDLINE    
Male hypogonadism is characterized by abnormally low serum testosterone levels associated with typical symptoms, including mood disturbance, sexual dysfunction, decreased muscle mass and strength, and decreased bone mineral density. By restoring serum testosterone levels to the normal range using testosterone replacement therapy, many of these symptoms can be relieved. For many years, injectable testosterone esters or surgically implanted testosterone pellets have been the preferred treatment for male hypogonadism. Recently, newer treatment modalities have been introduced, including transdermal patches and gels. The development of a mucoadhesive sustained-release buccal tablet is the latest innovation, which will provide patients with an additional option. The availability of new treatment modalities has helped to renew interest in the management of male hypogonadism, highlighting the need to address a number of important but previously neglected questions in testosterone replacement therapy. These include the risks and benefits of treatment in different patient populations (e.g. the elderly) and the need for evidence-based diagnosis and treatment monitoring guidelines. While some recommendations have been developed in individual countries, up-to-date, internationally accepted evidence-based guidelines that take into account national differences in clinical practice and healthcare delivery would optimize patient care universally.
E Nieschlag; H M Behre; P Bouchard; J J Corrales; T H Jones; G K Stalla; S M Webb; F C W Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2004-08-05
Journal Detail:
Title:  Human reproduction update     Volume:  10     ISSN:  1355-4786     ISO Abbreviation:  Hum. Reprod. Update     Publication Date:    2004 Sep-Oct
Date Detail:
Created Date:  2004-08-20     Completed Date:  2005-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9507614     Medline TA:  Hum Reprod Update     Country:  England    
Other Details:
Languages:  eng     Pagination:  409-19     Citation Subset:  IM    
Institute of Reproductive Medicine of the University Domagkstr 11, D-48129 Munster, Germany.
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MeSH Terms
Androgens / therapeutic use*
Hormone Replacement Therapy / trends*
Hypogonadism / drug therapy*
Testosterone / therapeutic use*
Reg. No./Substance:
0/Androgens; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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