Document Detail


Testosterone exacerbates hypertension and reduces pressure-natriuresis in male spontaneously hypertensive rats.
MedLine Citation:
PMID:  9453341     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies were performed in intact male and female, gonadectomized male and female, and gonadectomized female rats given testosterone for 5 weeks to investigate the role played by testosterone in altered blood pressure control and pressure-natriuresis in male SHR. Serum testosterone levels reached a peak at 12 weeks of age in intact male SHR. Systolic blood pressure, measured weekly from 5 to 20 weeks of age, was similar between groups until 12 weeks of age when blood pressure became higher in males (195+/-3 mm Hg) than in females (168+/-3 mm Hg) or males castrated at 4 weeks (173+/-4 mm Hg). At 17 to 19 weeks direct measurement of arterial pressure in anesthetized rats confirmed that mean arterial pressure was higher in male (182+/-1 mm Hg) than in female (159+/-2 mm Hg) and castrated male SHR (159+/-2 mm Hg). In addition, testosterone (5 mg in Silastic pellets, SC for 5 weeks) administered to ovariectomized (ovx+T) females caused arterial pressure to increase by mm 11% (175+/-2 mm Hg), which was significantly higher than in intact female, castrated male, or untreated ovariectomized (ovx) female SHR (158+/-2 mm Hg). Acute pressure-natriuresis was blunted in male SHR compared with females, castrated males, or ovx females, in which this relationship was similar. Pressure-natriuresis was also blunted in ovx+T females as found in intact male SHR. These data support the hypothesis that male sex hormones contribute to the exacerbation of hypertension in SHR by reducing pressure-natriuresis.
Authors:
J F Reckelhoff; H Zhang; J P Granger
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  31     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-20     Completed Date:  1998-02-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  435-9     Citation Subset:  IM    
Affiliation:
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505, USA. jfr@fiona.umsmed.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*
Body Weight / drug effects
Female
Glomerular Filtration Rate / drug effects
Hematocrit
Hemodynamics / drug effects*,  physiology
Hypertension / physiopathology*
Kidney / drug effects,  physiology,  physiopathology
Male
Natriuresis / drug effects*
Orchiectomy
Organ Size / drug effects
Ovariectomy
Rats
Rats, Inbred SHR
Renal Circulation / drug effects
Sex Characteristics
Systole
Testosterone / blood,  pharmacology*
Vascular Resistance / drug effects
Grant Support
ID/Acronym/Agency:
HL 38499/HL/NHLBI NIH HHS; HL 51971/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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