Document Detail


Testosterone and cardiovascular disease: An old idea with modern clinical implications.
MedLine Citation:
PMID:  20869058     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The role of sex steroid hormones in modulating vascular function in men is of great importance, given that androgen deficiency is strongly associated with common medical conditions including metabolic syndrome, obesity, diabetes, hypertension and atherosclerosis. Testosterone deficiency afflicts approximately 30% of men ages 40-79 years. Testosterone replacement in deficient men with such co-morbidities ameliorates or partially reverses their progression. Studies in animal and humans suggest that androgen deficiency is associated with increased triglycerides (TGs), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C). Emerging evidence indicates that androgens may provide a protective effect against the development and/or progression of atherosclerosis in men.
Authors:
Abdulmaged M Traish; Kyriakos E Kypreos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Atherosclerosis     Volume:  214     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  244-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Biochemistry and Urology, Boston University School of Medicine, Laboratories for Sexual Medicine, Institute for Sexual Medicine, Center for Advanced Biomedical Research, 700 Albany Street, W607, Boston, MA 02118, United States.
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