| Testosterone and blood pressure regulation. | |
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MedLine Citation:
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PMID: 18319594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There is substantial evidence that androgens may play a role in determining sex-specific blood pressure. Men are at higher risk for developing coronary heart disease or hypertension compared to premenopausal women. However, effects of androgens on the renal and cardiovascular system are complex. This review provides a critical overview of testosterone actions. METHODS: We searched Pubmed library for experimental, animal and clinical studies, using the keywords 'blood pressure', 'hypertension', 'testosterone' and 'androgens'. RESULTS: While acute administration of testosterone seems to decrease vascular tone, the long-term net effect of androgens appears to be vasoconstriction via upregulation of thromboxane A2 expression, norepinephrine synthesis, angiotensin II expression, and endothelin-1 action. Furthermore, androgens cause cardiac hypertrophy, promote atherosclerosis, vascular remodelling and stimulate renal prohypertensive processes involving the renin-angiotensin-aldosterone system. Androgens seem to promote oxidative stress in the kidney and may also play a role in the differentiation of brain areas involved in blood pressure regulation. CONCLUSION: The effects of sex steroids on different parts of the renal-vascular system are complex and often contradictory. In sum, net effects of androgen action seem to be vasoconstriction, atherosclerosis and stimulation of the renin-angiotensin-aldosterone system. Therefore, androgens may determine blood pressure and the prevalence of cardiovascular disease. |
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Authors:
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Tina Kienitz; Marcus Quinkler |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-03-04 |
Journal Detail:
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Title: Kidney & blood pressure research Volume: 31 ISSN: 1423-0143 ISO Abbreviation: Kidney Blood Press. Res. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-04-30 Completed Date: 2008-06-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610505 Medline TA: Kidney Blood Press Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 71-9 Citation Subset: IM |
Copyright Information:
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Copyright 2008 S. Karger AG, Basel. |
Affiliation:
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Clinical Endocrinology, Department of Internal Medicine, Gastroenterology, Hepatology and Endocrinology, Charité Campus Mitte, Charité Universitatsmedizin Berlin, Berlin, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atherosclerosis / physiopathology Blood Pressure / physiology* Disease Models, Animal Female Humans Hypertension / physiopathology* Male Renin-Angiotensin System / physiology* Sex Factors Testosterone / physiology* Vasoconstriction / physiology |
| Chemical | |
Reg. No./Substance:
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58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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