Document Detail


Testosterone administration in severe burns ameliorates muscle catabolism.
MedLine Citation:
PMID:  11588456     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the effects of testosterone administration on muscle protein metabolism after severe burn injury. We hypothesized that restoration of blood testosterone concentrations would restore an important anabolic stimulus to skeletal muscle, and would further increase the anabolic response of muscle to amino acid supplementation. DESIGN: Pre- and postintervention trial conducted between September 1997 and July 1999. SETTING: Burn intensive care unit. PATIENTS: Six severely burned male patients (>70% total body surface area). INTERVENTION: Testosterone enanthate, 200 mg/wk (intramuscularly), for 2 wks. MEASUREMENTS AND MAIN RESULTS: Muscle protein synthesis, breakdown, and amino acid kinetics were determined. After a basal period in each study, we subsequently investigated the response to acute amino acid supplementation during enteral feeding. Total testosterone increased significantly from baseline to the low normal range after 1 wk, and to upper normal range after two injections (p <.001). Protein synthesis was unchanged, however, protein synthetic efficiency increased 2-fold (p <.01). Protein breakdown decreased almost 2-fold after testosterone enanthate (p <.05), resulting in an improvement in net amino acid balance to a value that was approximately zero (p <.0001). Amino acid supplementation at either time point provided no additional effects. CONCLUSIONS: Restoration of blood testosterone can ameliorate the muscle catabolism of severe burn injury with normal feedings.
Authors:
A A Ferrando; M Sheffield-Moore; S E Wolf; D N Herndon; R R Wolfe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Critical care medicine     Volume:  29     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-05     Completed Date:  2001-11-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1936-42     Citation Subset:  AIM; IM; S    
Affiliation:
Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biopsy, Needle
Burn Units
Burns / diagnosis*,  drug therapy*,  surgery
Energy Metabolism
Follow-Up Studies
Humans
Injections, Intramuscular
Injury Severity Score
Male
Middle Aged
Muscle Proteins / drug effects*,  metabolism*
Muscle, Skeletal / drug effects,  metabolism*
Probability
Testosterone / administration & dosage*,  analogs & derivatives
Treatment Outcome
Grant Support
ID/Acronym/Agency:
GM 57295-02/GM/NIGMS NIH HHS; M01 RR-00073/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Muscle Proteins; 315-37-7/testosterone enanthate; 58-22-0/Testosterone
Comments/Corrections
Comment In:
Crit Care Med. 2001 Oct;29(10):2032-3   [PMID:  11588483 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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