Document Detail

Testosterone administration in severe burns ameliorates muscle catabolism.
MedLine Citation:
PMID:  11588456     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the effects of testosterone administration on muscle protein metabolism after severe burn injury. We hypothesized that restoration of blood testosterone concentrations would restore an important anabolic stimulus to skeletal muscle, and would further increase the anabolic response of muscle to amino acid supplementation. DESIGN: Pre- and postintervention trial conducted between September 1997 and July 1999. SETTING: Burn intensive care unit. PATIENTS: Six severely burned male patients (>70% total body surface area). INTERVENTION: Testosterone enanthate, 200 mg/wk (intramuscularly), for 2 wks. MEASUREMENTS AND MAIN RESULTS: Muscle protein synthesis, breakdown, and amino acid kinetics were determined. After a basal period in each study, we subsequently investigated the response to acute amino acid supplementation during enteral feeding. Total testosterone increased significantly from baseline to the low normal range after 1 wk, and to upper normal range after two injections (p <.001). Protein synthesis was unchanged, however, protein synthetic efficiency increased 2-fold (p <.01). Protein breakdown decreased almost 2-fold after testosterone enanthate (p <.05), resulting in an improvement in net amino acid balance to a value that was approximately zero (p <.0001). Amino acid supplementation at either time point provided no additional effects. CONCLUSIONS: Restoration of blood testosterone can ameliorate the muscle catabolism of severe burn injury with normal feedings.
A A Ferrando; M Sheffield-Moore; S E Wolf; D N Herndon; R R Wolfe
Related Documents :
2569016 - The effects of tritium on embryo development: the embryotoxic effects of [3h]tryptophan.
1262176 - Incorporation of glutamic acid into soluble protein as a function of age.
18636966 - The mitochondrial pool of free amino acids reflects the composition of mitochondrial dn...
8267616 - Determination of the human liver udp-glucuronosyltransferase 2b4 domains involved in th...
6513616 - Effects of prolonged guanidinoethanesulphonate administration on taurine and other amin...
7893736 - On the mechanism of stimulation of peroxisomal beta-oxidation in rat heart by partially...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Critical care medicine     Volume:  29     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-05     Completed Date:  2001-11-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1936-42     Citation Subset:  AIM; IM; S    
Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biopsy, Needle
Burn Units
Burns / diagnosis*,  drug therapy*,  surgery
Energy Metabolism
Follow-Up Studies
Injections, Intramuscular
Injury Severity Score
Middle Aged
Muscle Proteins / drug effects*,  metabolism*
Muscle, Skeletal / drug effects,  metabolism*
Testosterone / administration & dosage*,  analogs & derivatives
Treatment Outcome
Grant Support
Reg. No./Substance:
0/Muscle Proteins; 315-37-7/testosterone enanthate; 58-22-0/Testosterone
Comment In:
Crit Care Med. 2001 Oct;29(10):2032-3   [PMID:  11588483 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Intravenous omeprazole in critically ill patients: a randomized, crossover study comparing 40 with 8...
Next Document:  Intraoperative prostaglandin E1 improves antimicrobial and inflammatory responses in alveolar immune...