| Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis. | |
| | |
MedLine Citation:
|
PMID: 20660052 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
CONTEXT: The mechanisms by which testosterone increases hemoglobin and hematocrit are unknown. OBJECTIVE: The aim was to test the hypothesis that testosterone-induced increase in hematocrit is associated with suppression of the iron regulatory peptide hepcidin. PARTICIPANTS: Healthy younger men (ages 19-35 yr; n = 53) and older men (ages 59-75 yr; n = 56) were studied. METHODS: Weekly doses of testosterone enanthate (25, 50, 125, 300, and 600 mg) were administered over 20 wk, whereas endogenous testosterone was suppressed by monthly GnRH agonist administration. Blood and serum parameters from each individual were measured at wk 0, 1, 2, 4, 8, and 20. Longitudinal analyses were performed to examine the relationship between hepcidin, hemoglobin, hematocrit, and testosterone while controlling for potential confounders. RESULTS: High levels of testosterone markedly suppressed serum hepcidin within 1 wk. Hepcidin suppression in response to testosterone administration was dose-dependent in older men and more pronounced than in young men, and this corresponded to a greater rise in hemoglobin in older men. Serum hepcidin levels at 4 and 8 wk were predictive of change in hematocrit from baseline to peak levels. CONCLUSION: Testosterone administration is associated with suppression of serum hepcidin. Greater increases in hematocrit in older men during testosterone therapy are related to greater suppression of hepcidin. |
| | |
Authors:
|
Eric Bachman; Rui Feng; Thomas Travison; Michelle Li; Gordana Olbina; Vaughn Ostland; Jagadish Ulloor; Anqi Zhang; Shehzad Basaria; Tomas Ganz; Mark Westerman; Shalender Bhasin |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-07-21 |
Journal Detail:
|
Title: The Journal of clinical endocrinology and metabolism Volume: 95 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-07 Completed Date: 2010-11-15 Revised Date: 2012-04-27 |
Medline Journal Info:
|
Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 4743-7 Citation Subset: AIM; IM |
Affiliation:
|
Department of Medicine, Boston University School of Medicine, 670 Albany Street, Boston, Massachusetts 02118, USA. eric.bachman@bmc.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aging / blood, physiology Antimicrobial Cationic Peptides / blood*, metabolism Dose-Response Relationship, Drug Double-Blind Method Down-Regulation / drug effects Drug Administration Schedule Humans Injections Leuprolide / administration & dosage Male Middle Aged Polycythemia / chemically induced* Testosterone / administration & dosage, pharmacology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
P30 AG031679/AG/NIA NIH HHS; U01AG14369/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antimicrobial Cationic Peptides; 0/hepcidin; 53714-56-0/Leuprolide; 58-22-0/Testosterone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Greater Arterial Stiffness in Polycystic Ovary Syndrome (PCOS) Is an Obesity--But Not a PCOS-Associa...
Next Document: Reversible sympathetic overactivity in hypertensive patients with primary aldosteronism.